Detailed information of TA system TA021867

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 1418407..1418966
• Replicon: chromosome
• Accession: NC_008769
• Organism: Mycobacterium bovis BCG str. Pasteur 1173P2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: G0THS1
• Locus tag: BCG_RS06760
• Protein ID: WP_003898789.1
• Coordinates: 1418407..1418700 (-)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: G0THS2
• Locus tag: BCG_RS06765
• Protein ID: WP_003406322.1
• Coordinates: 1418697..1418966 (-)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BCG_RS06735	1414000..1414260	+	261	WP_003406302.1	type II toxin-antitoxin system antitoxin VapB33	-
BCG_RS06740	1414257..1414688	+	432	WP_003406304.1	type II toxin-antitoxin system VapC family toxin	-
BCG_RS06745	1414711..1416399	-	1689	WP_003910308.1	PE family protein	-
BCG_RS06750	1416579..1417439	+	861	WP_003406306.1	hypothetical protein	-
BCG_RS06755	1417520..1418350	-	831	WP_003898788.1	SDR family NAD(P)-dependent oxidoreductase	-
BCG_RS06760	1418407..1418700	-	294	WP_003898789.1	type II toxin-antitoxin system mRNA interferase RelE	Toxin
BCG_RS06765	1418697..1418966	-	270	WP_003406322.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
BCG_RS06770	1419079..1422774	-	3696	WP_010950509.1	multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit	-
BCG_RS06775	1422916..1423704	-	789	WP_010950510.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (9-88)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11031.57 Da
• Isoelectric Point: 9.6275

>T21867 WP_003898789.1 NC_008769:c1418700-1418407 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
VSDDHPYHVAITATAARDLQRLPEKIAAACVEFVFGPLLNNPHRLGKPLRNDLEGLHSARRGDYRVVYAIDDGHHRVEII
HIARRSASYRMNPCRPR

Nucleotide

• Length: 294 bp

>T21867 NC_008769:c1418700-1418407 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
GTGAGCGACGACCATCCCTACCACGTGGCGATCACCGCGACAGCGGCACGCGACCTGCAACGCTTACCCGAAAAGATCGC
CGCCGCATGTGTCGAGTTTGTTTTCGGACCGCTGCTTAACAACCCGCATAGGTTGGGCAAGCCGCTGCGCAATGACCTTG
AAGGCCTCCACTCAGCCCGCCGCGGTGATTACCGCGTCGTCTACGCCATCGACGACGGCCACCACCGAGTCGAGATCATC
CACATCGCTCGTCGCAGTGCCAGCTACCGAATGAACCCGTGCCGGCCACGTTAA

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 9766.97 Da
• Isoelectric Point: 4.8615

>AT21867 WP_003406322.1 NC_008769:c1418966-1418697 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
MAVVPLGEVRNRLSEYVAEVELTHERITITRHGHPAAVLISADDLASIEETLEVLRTPGASEAIREGLADVAAGRFVSND
EIRNRYTAR

Nucleotide

• Length: 270 bp

>AT21867 NC_008769:c1418966-1418697 [Mycobacterium tuberculosis variant bovis BCG str. Pasteur 1173P2]
ATGGCTGTTGTCCCACTGGGCGAAGTCCGCAATCGCCTCTCTGAGTACGTCGCCGAAGTTGAGCTGACACACGAGCGCAT
CACGATAACCCGGCACGGTCATCCGGCGGCGGTATTGATCTCGGCCGATGACCTGGCGTCCATCGAGGAAACGCTGGAGG
TGCTACGCACCCCTGGCGCCAGCGAGGCCATTCGTGAAGGCCTCGCCGATGTTGCCGCAGGGCGCTTCGTGAGCAACGAC
GAGATCCGCAACCGTTACACCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: G0THS1

Antitoxin

• AlphaFold DB: G0THS2