Detailed information of TA system TA218624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 1748307..1748829
• Replicon: chromosome
• Accession: NZ_CP084433
• Organism: Edwardsiella piscicida strain S07-534

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: DCF40_RS08130
• Protein ID: WP_069578568.1
• Coordinates: 1748307..1748588 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A411H7D8
• Locus tag: DCF40_RS08135
• Protein ID: WP_069578569.1
• Coordinates: 1748578..1748829 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCF40_RS08115 (DCF40_08115)	1743692..1744468	+	777	WP_225857691.1	hypothetical protein	-
DCF40_RS08120 (DCF40_08120)	1744461..1746123	+	1663	Protein_1550	terminase	-
DCF40_RS08125 (DCF40_08125)	1746120..1748234	+	2115	WP_069578567.1	portal protein	-
DCF40_RS08130 (DCF40_08130)	1748307..1748588	-	282	WP_069578568.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
DCF40_RS08135 (DCF40_08135)	1748578..1748829	-	252	WP_069578569.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
DCF40_RS08140 (DCF40_08140)	1749107..1750108	+	1002	WP_069578570.1	hypothetical protein	-
DCF40_RS08145 (DCF40_08145)	1750126..1751364	+	1239	WP_069578572.1	N4-gp56 family major capsid protein	-
DCF40_RS08150 (DCF40_08150)	1751423..1751818	+	396	WP_069578573.1	hypothetical protein	-
DCF40_RS08155 (DCF40_08155)	1751860..1752303	+	444	WP_069578574.1	hypothetical protein	-
DCF40_RS08160 (DCF40_08160)	1752369..1752884	+	516	WP_225857693.1	hypothetical protein	-
DCF40_RS08165 (DCF40_08165)	1752884..1753546	+	663	WP_069578577.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	1695641..1774137	78496

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10738.62 Da
• Isoelectric Point: 10.6993

>T218624 WP_069578568.1 NZ_CP084433:c1748588-1748307 [Edwardsiella piscicida]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHIPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNDVYLAADGR

Nucleotide

• Length: 282 bp

>T218624 NZ_CP116067:c1144213-1144111 [Escherichia coli]
GCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTGTTCGGTCTCTTTTT

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9154.26 Da
• Isoelectric Point: 3.8074

>AT218624 WP_069578569.1 NZ_CP084433:c1748829-1748578 [Edwardsiella piscicida]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAENAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT218624 NZ_CP116067:1144073-1144344 [Escherichia coli]
AAAGTCAGCGAAGGGAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCTCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTGGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Structures

Antitoxin

• AlphaFold DB: A0A411H7D8