Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 1711626..1712191 Replicon chromosome
Accession NZ_CP084433
Organism Edwardsiella piscicida strain S07-534

Toxin (Protein)


Gene name higB Uniprot ID -
Locus tag DCF40_RS07905 Protein ID WP_069578523.1
Coordinates 1711626..1711904 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag DCF40_RS07910 Protein ID WP_069578525.1
Coordinates 1711904..1712191 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF40_RS07875 (DCF40_07875) 1707934..1708230 - 297 WP_012848441.1 putative quinol monooxygenase -
DCF40_RS07880 (DCF40_07880) 1708272..1708667 - 396 WP_015461418.1 VOC family protein -
DCF40_RS07885 (DCF40_07885) 1708887..1709168 - 282 WP_015461419.1 ribbon-helix-helix domain-containing protein -
DCF40_RS07890 (DCF40_07890) 1709448..1709852 - 405 WP_226088389.1 tyrosine-type recombinase/integrase -
DCF40_RS07895 (DCF40_07895) 1710197..1711291 - 1095 WP_069578521.1 tyrosine-type recombinase/integrase -
DCF40_RS07900 (DCF40_07900) 1711278..1711526 - 249 WP_015871361.1 excisionase -
DCF40_RS07905 (DCF40_07905) 1711626..1711904 + 279 WP_069578523.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DCF40_RS07910 (DCF40_07910) 1711904..1712191 + 288 WP_069578525.1 HigA family addiction module antitoxin Antitoxin
DCF40_RS07915 (DCF40_07915) 1712274..1712933 - 660 WP_071890273.1 hypothetical protein -
DCF40_RS07920 (DCF40_07920) 1713443..1714201 - 759 WP_069578527.1 antA/AntB antirepressor family protein -
DCF40_RS07925 (DCF40_07925) 1714951..1716336 + 1386 WP_069578529.1 hypothetical protein -
DCF40_RS07930 (DCF40_07930) 1716530..1717030 - 501 WP_069578531.1 AAA family ATPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1695641..1774137 78496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-1

(1-92)

Antitoxin

Cro/C1-type helix-turn-helix domain

(10-67)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10614.12 Da        Isoelectric Point: 7.3580

>T218622 WP_069578523.1 NZ_CP084433:1711626-1711904 [Edwardsiella piscicida]
MIKSFKHQGLKKFFLNNDSGGLEQHVVPRIRTRLTTIDAADCIDGINMPGYDLHPLKGDRKDIWSIKVSGNWRITFRFID
GDAEILNLEDYH

Download         Length: 279 bp

>T218622 NZ_CP116067:802683-802973 [Escherichia coli]
ATGCTGCCCATTTTATGGCTACCTTCTGCGCGTGATGATTTGCGTCAGATCGTAGCCTATATTGCCAAGGAAAACCCTCC
CGCTGCACGTAGACTAAAAATACGCATTGAAACATCAGTTTTGTCACTTACTGAACACCCTTACCTGTATCCACCAAGCG
AAAGAGCTCTAGGCCTTCGTGAGATAGTGACCCATCCTAACTACATAATACTTTACCGAGTAACAGCATCTAACATCGAG
ATCGTAAATGTAGTTCACTCACGAAGGCAGTATCCAAACAAAAGCTGTTAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10462.10 Da        Isoelectric Point: 7.4759

>AT218622 WP_069578525.1 NZ_CP084433:1711904-1712191 [Edwardsiella piscicida]
MKMANPAHPGEIIAETLEDMHISLRQFAKAMDIAPSTASRLISGHTSVTPEMALRLSVVLGSTAETWLKIQNHYSLNEAR
KTTDLCHLHRLVVAS

Download         Length: 288 bp

>AT218622 NZ_CP116067:802492-802683 [Escherichia coli]
ATGAGTACAGTCCTTTCCCCGATAATTTCAGAATTTGAAACAATCGAACAAGAAAACAGCTATAACGAATGGTTACGCAC
CAAAGTGGCAGCAAGCCTCGCAGACCCCCGTCCTGCAATTCCGCATGACGAAGTAATGGCTGAAATGGAAAACCTTATTG
CGCAAATAGCTTCGACGAACAGGAGTGAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References