Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 2933905..2934637 Replicon chromosome
Accession NZ_CP084429
Organism Edwardsiella piscicida strain S07-346

Toxin (Protein)


Gene name ypjF Uniprot ID A0A411H496
Locus tag DCF38_RS13525 Protein ID WP_015683453.1
Coordinates 2934308..2934637 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A411H489
Locus tag DCF38_RS13520 Protein ID WP_015683452.1
Coordinates 2933905..2934270 (+) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DCF38_RS13485 (DCF38_13485) 2929053..2929535 + 483 WP_012849568.1 SsrA-binding protein SmpB -
DCF38_RS13495 (DCF38_13495) 2930139..2931380 + 1242 WP_015683438.1 integrase -
DCF38_RS13500 (DCF38_13500) 2931465..2932673 - 1209 WP_012848447.1 IS256-like element ISEic2 family transposase -
DCF38_RS13505 (DCF38_13505) 2932747..2933106 + 360 Protein_2609 antirestriction protein -
DCF38_RS13510 (DCF38_13510) 2933119..2933661 + 543 WP_041692659.1 DNA repair protein RadC -
DCF38_RS13515 (DCF38_13515) 2933658..2933879 + 222 WP_015683451.1 DUF987 domain-containing protein -
DCF38_RS13520 (DCF38_13520) 2933905..2934270 + 366 WP_015683452.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
DCF38_RS13525 (DCF38_13525) 2934308..2934637 + 330 WP_015683453.1 TA system toxin CbtA family protein Toxin
DCF38_RS13530 (DCF38_13530) 2935017..2935313 + 297 WP_012849576.1 YciI family protein -
DCF38_RS13535 (DCF38_13535) 2935430..2935816 - 387 WP_012849577.1 RidA family protein -
DCF38_RS13540 (DCF38_13540) 2935853..2936179 - 327 WP_012849578.1 AzlD domain-containing protein -
DCF38_RS13545 (DCF38_13545) 2936172..2936909 - 738 WP_172454870.1 AzlC family ABC transporter permease -
DCF38_RS13550 (DCF38_13550) 2936973..2938256 - 1284 WP_012849580.1 L-serine ammonia-lyase, iron-sulfur-dependent, subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2931465..2932673 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-108)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12617.29 Da        Isoelectric Point: 9.5061

>T218577 WP_015683453.1 NZ_CP084429:2934308-2934637 [Edwardsiella piscicida]
MQTLSSHPTRSTQPYLSPVETWQRLLTHLFSQHYGLTLNDTPFSNETTIREHIDAGVSLSDAVNFLVEKYELIRIDRKGF
SWQQQTPYISVVDILRARRNTGLLKTNVK

Download         Length: 330 bp

>T218577 NZ_CP116044:c1363912-1363694 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13477.21 Da        Isoelectric Point: 5.8743

>AT218577 WP_015683452.1 NZ_CP084429:2933905-2934270 [Edwardsiella piscicida]
MNNHSESGTKPENLTCQQWGLKRTITPCFGARLVQEGNRVHFLADRAGFNGAFSDNDALRLDQAFPLMLKQLELMLTSGE
LSPLHQHCVTLYHNGLTCEADTLGSCGYVYIAIYPDQPEPH

Download         Length: 366 bp

>AT218577 NZ_CP116044:c1364312-1363938 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGCAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411H496

Antitoxin

Source ID Structure
AlphaFold DB A0A411H489

References