Detailed information of TA system TA218571

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yfjZ-ypjF/CbtA-CbeA
• Location: 881377..882083
• Replicon: chromosome
• Accession: NZ_CP084428
• Organism: Edwardsiella piscicida strain S07-275

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: DCF36_RS03965
• Protein ID: WP_116541156.1
• Coordinates: 881715..882083 (+)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: yfjZ
• Uniprot ID: -
• Locus tag: DCF36_RS03960
• Protein ID: WP_116541155.1
• Coordinates: 881377..881718 (+)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DCF36_RS03920 (DCF36_03920)	876636..877460	+	825	WP_116541149.1	DUF932 domain-containing protein	-
DCF36_RS03925 (DCF36_03925)	877669..878379	+	711	WP_116541150.1	DeoR family transcriptional regulator	-
DCF36_RS03930 (DCF36_03930)	878405..878512	+	108	WP_116541151.1	DUF4339 domain-containing protein	-
DCF36_RS03935 (DCF36_03935)	878671..879738	+	1068	WP_116541269.1	hypothetical protein	-
DCF36_RS03940 (DCF36_03940)	879894..880094	+	201	Protein_749	DUF905 domain-containing protein	-
DCF36_RS03945 (DCF36_03945)	880180..880638	+	459	WP_116541153.1	antirestriction protein	-
DCF36_RS03950 (DCF36_03950)	880647..881129	+	483	WP_116541154.1	RadC family protein	-
DCF36_RS03955 (DCF36_03955)	881138..881359	+	222	WP_000691980.1	DUF987 family protein	-
DCF36_RS03960 (DCF36_03960)	881377..881718	+	342	WP_116541155.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
DCF36_RS03965 (DCF36_03965)	881715..882083	+	369	WP_116541156.1	TA system toxin CbtA family protein	Toxin
DCF36_RS03970 (DCF36_03970)	882429..883625	+	1197	WP_116541158.1	tyrosine-type recombinase/integrase	-
DCF36_RS03975 (DCF36_03975)	883804..884142	+	339	Protein_756	tyrosine-type recombinase/integrase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	860919..902409	41490

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-111)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13584.81 Da
• Isoelectric Point: 7.7465

>T218571 WP_116541156.1 NZ_CP084428:881715-882083 [Edwardsiella piscicida]
MKNLPATISLAAKPCLSPVAIWQMLLTRLLEQHYGLMLSDTPFSDETVIKEHIDAGITLANAVNFLVEKYELVRIDRNGF
TSQVQAPYLTATDILQARGACGLMSRCSYREVSNIVLSRSRL

Nucleotide

• Length: 369 bp

>T218571 NZ_CP116043:c38783-38502 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGCGCATCTGGCTACAGACTTGTATATCAAGTTATTGATGAGAAAGTCGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTCTACCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12747.47 Da
• Isoelectric Point: 6.9463

>AT218571 WP_116541155.1 NZ_CP084428:881377-881718 [Edwardsiella piscicida]
MSNPTWGLQRDITPCLGARLVQEGNRLHYLADRASITGKFSDAESLKLDVVFPHFISQMESMLTTGEMNPRHAHCVTLYH
NGFNCEADTLGSCGYVYIAIYPPQRKQISREQT

Nucleotide

• Length: 342 bp

>AT218571 NZ_CP116043:c39024-38773 [Salmonella enterica subsp. enterica serovar 1,4,[5],12:i:-]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA