Detailed information of TA system TA218546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 4880236..4881055
• Replicon: chromosome
• Accession: NZ_CP084415
• Organism: Klebsiella michiganensis strain YL6-1

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: LDP80_RS23395
• Protein ID: WP_004110819.1
• Coordinates: 4880798..4881055 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: LDP80_RS23390
• Protein ID: WP_014837489.1
• Coordinates: 4880236..4880787 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDP80_RS23360 (LDP80_23380)	4876160..4876933	+	774	WP_088168442.1	Zygote formation protein zyg1	-
LDP80_RS23365 (LDP80_23385)	4877244..4877717	+	474	WP_032693194.1	hypothetical protein	-
LDP80_RS23370 (LDP80_23390)	4877986..4878335	-	350	Protein_4602	type II toxin-antitoxin system VapC family toxin	-
LDP80_RS23375 (LDP80_23395)	4878398..4878556	-	159	Protein_4603	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
LDP80_RS23380 (LDP80_23400)	4878590..4879336	-	747	WP_223226754.1	class I SAM-dependent methyltransferase	-
LDP80_RS23385 (LDP80_23405)	4879760..4880122	-	363	Protein_4605	class I SAM-dependent methyltransferase	-
LDP80_RS23390 (LDP80_23410)	4880236..4880787	-	552	WP_014837489.1	N-acetyltransferase	Antitoxin
LDP80_RS23395 (LDP80_23415)	4880798..4881055	-	258	WP_004110819.1	YjhX family toxin	Toxin
LDP80_RS23400 (LDP80_23420)	4881731..4882915	+	1185	WP_014228054.1	mannonate dehydratase	-
LDP80_RS23405 (LDP80_23425)	4882989..4884464	+	1476	WP_014228053.1	fructuronate reductase	-
LDP80_RS23410 (LDP80_23430)	4884603..4885379	+	777	WP_004847986.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (22-130)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T218546 WP_004110819.1 NZ_CP084415:c4881055-4880798 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T218546 NZ_CP116035:c4506833-4506660 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 19902.64 Da
• Isoelectric Point: 6.4913

>AT218546 WP_014837489.1 NZ_CP084415:c4880787-4880236 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGAGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPGAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT218546 NZ_CP116035:c4507157-4506861 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2