Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-HipB |
| Location | 2735719..2737307 | Replicon | chromosome |
| Accession | NZ_CP084397 | ||
| Organism | Klebsiella pneumoniae subsp. pneumoniae strain MRSN752019 | ||
Toxin (Protein)
| Gene name | hipA | Uniprot ID | W8UI36 |
| Locus tag | KF608_RS16090 | Protein ID | WP_002904792.1 |
| Coordinates | 2735719..2737041 (-) | Length | 441 a.a. |
Antitoxin (Protein)
| Gene name | hipB | Uniprot ID | A0A0H3GXD8 |
| Locus tag | KF608_RS16095 | Protein ID | WP_002904790.1 |
| Coordinates | 2737041..2737307 (-) | Length | 89 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| KF608_RS16075 (2730775) | 2730775..2733276 | + | 2502 | WP_032433099.1 | fimbria/pilus outer membrane usher protein | - |
| KF608_RS16080 (2733264) | 2733264..2734268 | + | 1005 | WP_032433097.1 | fimbrial protein | - |
| KF608_RS16085 (2734410) | 2734410..2735702 | + | 1293 | WP_002904794.1 | glycoside hydrolase family 10 protein | - |
| KF608_RS16090 (2735719) | 2735719..2737041 | - | 1323 | WP_002904792.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| KF608_RS16095 (2737041) | 2737041..2737307 | - | 267 | WP_002904790.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
| KF608_RS16100 (2737693) | 2737693..2738019 | - | 327 | WP_002904788.1 | hydroxyisourate hydrolase | - |
| KF608_RS16105 (2738016) | 2738016..2738516 | - | 501 | WP_032433095.1 | 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase | - |
| KF608_RS16110 (2738494) | 2738494..2739873 | - | 1380 | WP_032433093.1 | nucleobase:cation symporter-2 family protein | - |
| KF608_RS16115 (2740219) | 2740219..2741373 | + | 1155 | WP_002904783.1 | FAD-dependent urate hydroxylase HpxO | - |
| KF608_RS16120 (2741354) | 2741354..2742277 | - | 924 | WP_002904781.1 | LysR family hpxDE operon transcriptional regulator HpxR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49171.46 Da Isoelectric Point: 7.5357
>T218504 WP_002904792.1 NZ_CP084397:c2737041-2735719 [Klebsiella pneumoniae subsp. pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL
Download Length: 1323 bp
>T218504 NZ_CP116005:c3970375-3970073 [Sphingosinicella microcystinivorans]
ATGGCGGGTAGGCGCGGCGGTTTTCGCCTGACGCCGCGCGCCGAAGCCGATCTCGAAGACATTTTCACCTACACGGCGGA
GCGCTGGTCGCTCATGCAGGCGGAGGACCATCACGCCGGTTTCGCTGCTGCGTTCGAAAAGCTCGGCAGCGGCGAGCGAT
CAGGCCGCGCCGCCGGTGTTCCCGGCGCATATCTCAAGTACGCGGTCGGCTCGCATCTCGTCTTTTATCGCGAGCCGGAG
AGCGAAATCATCGTGGTTCGCGTCCTGCATCAGCGGATGGATGTGGGGCGGTATCTGGAATAG
ATGGCGGGTAGGCGCGGCGGTTTTCGCCTGACGCCGCGCGCCGAAGCCGATCTCGAAGACATTTTCACCTACACGGCGGA
GCGCTGGTCGCTCATGCAGGCGGAGGACCATCACGCCGGTTTCGCTGCTGCGTTCGAAAAGCTCGGCAGCGGCGAGCGAT
CAGGCCGCGCCGCCGGTGTTCCCGGCGCATATCTCAAGTACGCGGTCGGCTCGCATCTCGTCTTTTATCGCGAGCCGGAG
AGCGAAATCATCGTGGTTCGCGTCCTGCATCAGCGGATGGATGTGGGGCGGTATCTGGAATAG
Antitoxin
Download Length: 89 a.a. Molecular weight: 9906.27 Da Isoelectric Point: 8.5912
>AT218504 WP_002904790.1 NZ_CP084397:c2737307-2737041 [Klebsiella pneumoniae subsp. pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW
Download Length: 267 bp
>AT218504 NZ_CP116005:c3970610-3970365 [Sphingosinicella microcystinivorans]
ATGGCACGAAACACGTCAATCTCGCTCGGCGATCATTTCAGCGGCTTCATCGAGACGCAGGTCAGCAGCGGTCGCTATGG
CTCGGCAAGCGACGTGGTGCGCGCAGGATTGCGCCTTCTCGAAGAGCGCGAGGCAAGAGTACGCGCGCTGCAGGCTGCGC
TTGCCGAGGGCGAGGCATCGGGCGAGCCGCGCCCGTTCGACAACACCGCCTTCCTGAACCGGATGCGCGCCCGGCATGGC
GGGTAG
ATGGCACGAAACACGTCAATCTCGCTCGGCGATCATTTCAGCGGCTTCATCGAGACGCAGGTCAGCAGCGGTCGCTATGG
CTCGGCAAGCGACGTGGTGCGCGCAGGATTGCGCCTTCTCGAAGAGCGCGAGGCAAGAGTACGCGCGCTGCAGGCTGCGC
TTGCCGAGGGCGAGGCATCGGGCGAGCCGCGCCCGTTCGACAACACCGCCTTCCTGAACCGGATGCGCGCCCGGCATGGC
GGGTAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E1CEC8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0H3GXD8 |