Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /COG5642-COG5654
Location 1661533..1662499 Replicon chromosome
Accession NZ_CP084336
Organism Yersinia pestis strain R

Toxin (Protein)


Gene name - Uniprot ID A0A0E8XJV6
Locus tag LDH64_RS07545 Protein ID WP_002210981.1
Coordinates 1661533..1661991 (-) Length 153 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID Q66A69
Locus tag LDH64_RS07550 Protein ID WP_002210982.1
Coordinates 1662053..1662499 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDH64_RS07515 (LDH64_07510) 1657347..1658012 + 666 WP_002210975.1 phage shock protein PspA -
LDH64_RS07520 (LDH64_07515) 1658174..1658401 + 228 WP_002210976.1 envelope stress response membrane protein PspB -
LDH64_RS07525 (LDH64_07520) 1658401..1658760 + 360 WP_002210977.1 envelope stress response membrane protein PspC -
LDH64_RS07530 (LDH64_07525) 1658845..1659087 + 243 WP_002216375.1 phage shock protein PspD -
LDH64_RS07535 (LDH64_07530) 1659068..1660465 + 1398 WP_002210979.1 YcjX family protein -
LDH64_RS07540 (LDH64_07535) 1660462..1661523 + 1062 WP_002210980.1 YcjF family protein -
LDH64_RS07545 (LDH64_07540) 1661533..1661991 - 459 WP_002210981.1 RES family NAD+ phosphorylase Toxin
LDH64_RS07550 (LDH64_07545) 1662053..1662499 - 447 WP_002210982.1 DUF2384 domain-containing protein Antitoxin
LDH64_RS07555 (LDH64_07550) 1662835..1664412 + 1578 WP_002210983.1 transcriptional regulator TyrR -
LDH64_RS07560 (LDH64_07555) 1664559..1665017 - 459 WP_002213775.1 IS200/IS605-like element IS1541B family transposase -
LDH64_RS07565 (LDH64_07560) 1665270..1665773 - 504 WP_002210984.1 thiol peroxidase -
LDH64_RS07570 (LDH64_07565) 1665936..1666910 + 975 WP_002210985.1 L-Ala-D/L-Glu epimerase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1664559..1665017 458


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(2-147)

Antitoxin

Antitoxin Xre

(15-147)


Sequences

Toxin        


Download         Length: 153 a.a.        Molecular weight: 16994.38 Da        Isoelectric Point: 4.8732

>T218436 WP_002210981.1 NZ_CP084336:c1661991-1661533 [Yersinia pestis]
MTLYRIVMRRYLASAWTGYGAEIYGGRWNHKGHAAIYLASSISLAMLETLAHIQDSSTLSEFELFQIEISDSSIMLLQPQ
DWPTDWRSDPAPVATMDVGTEWLESESSVGLLVPSTLVPSENNLLVNPHHKDFPACLASVKPLSFVFDPRLK

Download         Length: 459 bp

>T218436 NZ_CP115952:c1099668-1099414 [Ralstonia solanacearum CFBP2957]
ATGAAAGCCAAACACCAGAAGACGCTGGAACTGATCTTTTCCCGCCCTACGCCAGCGAGCGTTAAGTGGGCCGATGCCGT
CGCGCTCATGAAAGAGTTGGGAGCAGAGTTGGAGGAACGCGAAGGTTCCCGCGTGGCCGTCTTTCTGTTTGGTCAAGTGA
AAGTGATGCATAGACCCCATCCATCGCCCGATATAGACAAGGGCGCTGTGGCGTCGATGCGTAAGTGGTTCGAGGAAAAC
GGAGTCAAGCCATGA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16401.94 Da        Isoelectric Point: 9.7155

>AT218436 WP_002210982.1 NZ_CP084336:c1662499-1662053 [Yersinia pestis]
MRAYRPNPATKMGTLWREIGLPASRGTILVDSIKMGFSVDVIDSIHLWASMPKAEILRATGIPSRSLTRRRTHDGRFTPE
ESERIARFVRVMDAAVDLFGGDKGKAITWMSTPIKGLGYRSPDSLLETETGALEVCDLIGRLEHGVFT

Download         Length: 447 bp

>AT218436 NZ_CP115952:c1099417-1099079 [Ralstonia solanacearum CFBP2957]
ATGATCAACGTCATGAACATCGGCGGCCATAAGGCTGTCATCGCCTACGACCCAGATATCGAAATGTTCCGTGGGGAGTT
TGTTGGCCTGAACGGTGGCGCCGATTTCTACGCTGCCGATGTGCCCGGCCTGCACCGCGAAGGCGAGTTGTCGCTGCGCG
TGTTTTTGGACGAGTGCGCACGGCGTGGCGTTGAACCGCAAAAGCACTTTTCTGGCAGGTTCGTCCTGCGCGTGGAGGGC
AAGGTGCATGAGGCCGCCGCCATTGCCGCCGCCGCGCGAGGCGTGAGCCTTAACCAATGGGCAGCCGATGTGCTGGAGCA
AGCCGCCGAAGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E8XJV6

Antitoxin

Source ID Structure
AlphaFold DB A0A0E8XFL1

References