Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 26657..27182 Replicon plasmid unnamed1
Accession NZ_CP084195
Organism Salmonella sp. A39

Toxin (Protein)


Gene name ccdB Uniprot ID I3W3D5
Locus tag LDO68_RS24040 Protein ID WP_001159863.1
Coordinates 26657..26962 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID M7S5D0
Locus tag LDO68_RS24045 Protein ID WP_000813641.1
Coordinates 26964..27182 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS24000 22036..22596 - 561 WP_000900095.1 inverse autotransporter beta domain-containing protein -
LDO68_RS24005 22752..23039 + 288 WP_071530243.1 hypothetical protein -
LDO68_RS24010 23316..23801 - 486 WP_000905606.1 membrane protein -
LDO68_RS24015 23795..24283 - 489 WP_001075507.1 CaiF/GrlA family transcriptional regulator -
LDO68_RS24020 24470..25021 - 552 WP_000545754.1 EAL domain-containing protein -
LDO68_RS24025 25030..25812 - 783 WP_000082169.1 site-specific integrase -
LDO68_RS24030 25847..26368 - 522 WP_000198608.1 hypothetical protein -
LDO68_RS24035 26365..26655 - 291 WP_001266176.1 hypothetical protein -
LDO68_RS24040 26657..26962 - 306 WP_001159863.1 type II toxin-antitoxin system toxin CcdB Toxin
LDO68_RS24045 26964..27182 - 219 WP_000813641.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
LDO68_RS24050 27858..28379 + 522 WP_010999942.1 hypothetical protein -
LDO68_RS24055 28423..28851 - 429 Protein_34 hypothetical protein -
LDO68_RS24060 28863..29159 + 297 WP_001687482.1 hypothetical protein -
LDO68_RS24065 29653..30642 + 990 WP_001527061.1 RepB family plasmid replication initiator protein -
LDO68_RS24070 30901..31345 - 445 Protein_37 tyrosine-type recombinase/integrase -
LDO68_RS24075 31514..31895 - 382 Protein_38 YgiW/YdeI family stress tolerance OB fold protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - spvB / spvC / fdeC / pefB / pefA / pefC / pefD / rck 1..93861 93861


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11587.48 Da        Isoelectric Point: 6.9787

>T218179 WP_001159863.1 NZ_CP084195:c26962-26657 [Salmonella sp. A39]
MQFKVYTCKRESRYRLFVDVQSDIIDTPGRRMAVPLVSARLLSEKVPRDLYPVMHIGDEPYRLLTTDMTSVPATVIGEEV
ADLSLRENDIKNAINLMFRGI

Download         Length: 306 bp

>T218179 NZ_CP115669:1652754-1653323 [Pseudomonas sp. PSE14]
ATGTTCAGACCGCTACCGATCACCTTGCAGCGCGGGGCCTTGCGCCTGGAGCCGATGGTGGAGGCCGACGTGCCCGAACT
GGTGAGCCTGGCGGAAGCGAACCGCGAGGTGCTGCAGTTCATGAGCGCGCCGGGGCGTCCAGACTGGTACCGCCAGGGCC
TTGCCGACCAGCGCGAGGGCCGTGCGCTGCCGCTGGTGGTGCGCCTGGGCAACGAGATCGTCGGCACCACGCGCTTCATG
GACTTCCTCCCGGCGCTGCCGGCCTGTGAGATCGGCGCCACTTGGCTGGACCAGGCGCAGCACGGCAGCGGCCTGAACGC
CACCATGAAGTACCTGATGCTGCGCCATGCCTTCGACAGCTGGAAGATGGTCCGCGTGCAGATCAAGACCGCCGCCAGCA
ACCTGCGCTCGCAGCGCGCCATCGAGAAGCTCGGCGCGGTGCGCGAGGGCGTGCTGCGCAACCACCGCCGCCTGGCCGGC
GGCCGCCTCGACGACACCATTCTCTACAGCATCACCGACCATGAGTGGCCGCAGGTGAAAGCCGCGCTGGAAGCCGGTTT
CAACGGCTGA

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8314.16 Da        Isoelectric Point: 4.5203

>AT218179 WP_000813641.1 NZ_CP084195:c27182-26964 [Salmonella sp. A39]
MKQRITVTVDSDSYQLLKAYDVNISGLVSTTMQNEARRLRAERWQEENREGMAEVASFIEANGSFADDNRNW

Download         Length: 219 bp

>AT218179 NZ_CP115669:1653390-1654241 [Pseudomonas sp. PSE14]
ATGACGGAACATCACGCGAGCGGCGAAAGAACCCGCTTCTGGCGCGCCCAGGAGCTGGGCGGCGTCGAGCTGCTGCACGC
GCGCTACATCGAGCAGGTGTTCGCGCCCCACGTCCACGAGGGCTTCGCCTTCGTGATGATCGAGCAGGGCGCGCAGCGCT
TCCACCATCGCGGCAGCGAGCATTTCGCCCCCACCGGCAGCGTGGTGCTGATCAACCCCGACGAGGTGCACACCGGCTCC
AAGGCCGATGAGGCGGGCTGGCTGTACCGCGGGTTCTACCCGGAGCTGGAGCAGGTTTCCGGGATTCTCGACGAGCTCGA
ACTGGGTCGTTCCGGCACGCCGTCCTTTGCCGCCAGCGTGTTGCAGGACCCGGAGCTGGTCCAGGTGTTGCTCGGTGCCC
ATCGCCTGCTGGAGTCCGAGGCCACTGTGCTGCAGCGCCAGACCTGCTGGCGCGAAGCCTTGTTGCTGCTGTTCCAGCGC
CACGCGCGGATTCCCGAGGTGCCGGCCGCCGGCAACGAACCCCTGGCGGTGGCGCGCGCTCGCGAGCTGCTGGGCGCGCG
GCTGATCGATCCGCCATCGTTGGAAGAGCTGGCGGCGGCGGTCGCTCTGTCGCCGTTCCATTTCGCCCGGGTGTTCCGCA
AGGCCACCGGCCTGCCGCCCCACGCCTGGCTCAAGCAGCGTCGCCTGGAGCAGGCTCGCGCCCTGCTCAAGCAGGGCTGC
GCGCCGGTGAACGTGGCGATGCACCTGGGCTTCGCCGACCAGAGCCATCTCAGCCGCCAGTTCAAGCAGGCCTACGGCGT
AGGCCCCGGCGAATACCGGCAGGCTTGCGCCCGATCGTTCAAGACGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I3W3D5

Antitoxin

Source ID Structure
AlphaFold DB A0A656ICA6

References