Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4248946..4249462 Replicon chromosome
Accession NZ_CP084194
Organism Salmonella sp. A39

Toxin (Protein)


Gene name relE Uniprot ID C0Q7A9
Locus tag LDO68_RS20825 Protein ID WP_000220578.1
Coordinates 4248946..4249230 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V7ISI8
Locus tag LDO68_RS20830 Protein ID WP_000212724.1
Coordinates 4249220..4249462 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS20810 (4244158) 4244158..4245810 + 1653 WP_000155057.1 alpha,alpha-phosphotrehalase -
LDO68_RS20815 (4246219) 4246219..4248357 + 2139 WP_000187818.1 anaerobic ribonucleoside-triphosphate reductase -
LDO68_RS20820 (4248478) 4248478..4248942 + 465 WP_001268859.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LDO68_RS20825 (4248946) 4248946..4249230 - 285 WP_000220578.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LDO68_RS20830 (4249220) 4249220..4249462 - 243 WP_000212724.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LDO68_RS20835 (4249540) 4249540..4251453 - 1914 WP_001212137.1 BglG family transcription antiterminator -
LDO68_RS20840 (4251470) 4251470..4252210 - 741 WP_000779263.1 KDGP aldolase family protein -
LDO68_RS20845 (4252207) 4252207..4253325 - 1119 WP_001139187.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
LDO68_RS20850 (4253309) 4253309..4254442 - 1134 WP_000459930.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10854.67 Da        Isoelectric Point: 10.0482

>T218175 WP_000220578.1 NZ_CP084194:c4249230-4248946 [Salmonella sp. A39]
MTYELEFDPRALKEWHKLGDTVKAQLKKKLADVLLNPRIDSARLNGLPDCYKIKLKSSGYRLVYQVRDDVVIVFVVAVGK
REHSAVYHDANKRL

Download         Length: 285 bp

>T218175 NZ_CP115668:2228231-2228470 [Cutibacterium sp. CBA3108]
ATGACCAAGGTGACAGTCGCGCCCATCACGTCAACGCTGAAGGGCTTGTCGAGCGAGGTACCACTGGACACCCGCAATGG
AGTCGACCATGCATGTGCGGCGTCCCTCGACAACGTGATGACGATTCCGGTATCCCTCCTAGGGCGCACCGTCGGCTTCC
TTCGCCCTGAGCAGGAGCATGACTTGGCCGTGGCGATGGTTCTTGCCTACGACTTGGAGATCTCCATTCTTGGCAATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8961.34 Da        Isoelectric Point: 5.0651

>AT218175 WP_000212724.1 NZ_CP084194:c4249462-4249220 [Salmonella sp. A39]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTLSDSEDALIQTVRERLSSPQKGIKVSLDDL

Download         Length: 243 bp

>AT218175 NZ_CP115668:2227918-2228151 [Cutibacterium sp. CBA3108]
GTGACGACACAGATTGCAGTGCGGCTTCCTGACGAGCTCGTCAGATTCTTGGATCAGAGTGTCGCCGATGGCATCGTCAC
GAGTCGGGCGGAGATGGTGAGTCGGGCCGTTGAGCGCGAGATGCGACACCAGGCGGCTGTTGCAGATGCCGCGATTCTTA
CCACCGACGGCCCCCGAGACGACCTCGACGAGTTAGTCGCATGGGCCGCCACCAACGCATTTCTTGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E876

Antitoxin

Source ID Structure
AlphaFold DB A0A5H5JRI5

References