Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4175920..4177543 Replicon chromosome
Accession NZ_CP084194
Organism Salmonella sp. A39

Toxin (Protein)


Gene name hipA Uniprot ID H9TH67
Locus tag LDO68_RS20435 Protein ID WP_000088046.1
Coordinates 4176218..4177543 (+) Length 442 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A5Z6V2D1
Locus tag LDO68_RS20430 Protein ID WP_024136327.1
Coordinates 4175920..4176213 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS20405 (4171792) 4171792..4173033 + 1242 WP_001053338.1 VWA domain-containing protein -
LDO68_RS24525 (4173124) 4173124..4173255 + 132 WP_000374059.1 hypothetical protein -
LDO68_RS20410 (4173596) 4173596..4173877 - 282 WP_000077926.1 hypothetical protein -
LDO68_RS20415 (4173927) 4173927..4174118 - 192 WP_000398480.1 hypothetical protein -
LDO68_RS20420 (4174210) 4174210..4174551 - 342 WP_001151575.1 hypothetical protein -
LDO68_RS20425 (4174885) 4174885..4175316 + 432 WP_011152969.1 hypothetical protein -
LDO68_RS20430 (4175920) 4175920..4176213 + 294 WP_024136327.1 helix-turn-helix transcriptional regulator Antitoxin
LDO68_RS20435 (4176218) 4176218..4177543 + 1326 WP_000088046.1 type II toxin-antitoxin system HipA family toxin Toxin
LDO68_RS20440 (4177604) 4177604..4177810 + 207 WP_000134171.1 hypothetical protein -
LDO68_RS20445 (4177912) 4177912..4178322 + 411 WP_000985911.1 hypothetical protein -
LDO68_RS20450 (4178335) 4178335..4179024 + 690 WP_225522439.1 HNH endonuclease signature motif containing protein -
LDO68_RS20455 (4179058) 4179058..4179761 - 704 Protein_3998 IS6-like element IS26 family transposase -
LDO68_RS20460 (4179824) 4179824..4180294 + 471 Protein_3999 recombinase family protein -
LDO68_RS20465 (4180359) 4180359..4181488 + 1130 WP_085959879.1 IS3-like element IS1133 family transposase -
LDO68_RS20470 (4181595) 4181595..4182398 + 804 WP_024261901.1 aminoglycoside O-phosphotransferase APH(3'')-Ib -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island aph(3'')-Ib / aph(6)-Id / blaTEM-1B / tet(A) - 4173596..4209641 36045


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(9-108)

Antitoxin

Cro/C1-type helix-turn-helix domain

(21-69)


Sequences

Toxin        


Download         Length: 442 a.a.        Molecular weight: 50249.20 Da        Isoelectric Point: 6.1927

>T218174 WP_000088046.1 NZ_CP084194:4176218-4177543 [Salmonella sp. A39]
MSRKQQRLVIWMNGIKVGYWEKSKGVDSLEYLPEWVADEQGRPLSLSLPFTPGNQVWRGNVVRDYFDNLLPDSEGIRRRL
AMRYKADSLEPFDLLTELGKDCVGAIQLLHDGDEPTDLYSVKYHPLTESEIAATLRNTTETLLPGRPEDNDDLRLSIAGA
QEKTALLWHEDRWCMPEGNTPTTHIFKLPLGLVGNMKADMSSSVENEWLCSVLLGQYGLPVARTQIAHFEDQKALVVERF
DRKWSGDGQWIIRLPQEDMCQALGVSPLRKYQADGGPGISEIMEVLSNSDRAERDKAQFFMTQIIFWMMAATDGHAKNFS
ISIGPQGRYHLTPNYDVLSAWPVIGHGNNQISWQKCKLAMAVRGSSNYYQIYRIQRRHWIRHGEITGLSKQQTEAMIEEI
IARTPGVIERVSGLLPDQFPQQLAESIFDGMRQQCRRLAEK

Download         Length: 1326 bp

>T218174 NZ_CP115668:499442-499870 [Cutibacterium sp. CBA3108]
ATGTTGCTCGTTGACGCCAATGTGCTGGTTTACGCGACTAACACGAGTGCTCAACATCACGAGGCTGCCCGGGCGTGGCT
GCTGGAGGAGTTGAACTCCGGAACTGAGGTTGTGGGGATGCCGTGGGTGTCTCTGCTGGGATTCATTCGCGTCTGTACCC
ATCCGCGTATCCTGGAGAACCCACTGACGGCAGAGCAGGCCATGTCGGTAGTGAATGCATGGTTGTCTCACCCGCGTGTT
GTGACGCCTGAACCGTCCGCCCGTCACGGTGCGCTGCTGGCTGGTCTCCTTGTGAAGGCCGGGACGGCTGGCAACCTCAC
CAATGACGCCCACCTAGCCGCCTTAGCACTCGAATTGAATGCGACCATGGTGACCTTCGACAGGGACTTTGGCCGTTTTG
ACGTCCGATTTCTGGTGCCGGGAAGCTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10946.35 Da        Isoelectric Point: 10.0925

>AT218174 WP_024136327.1 NZ_CP084194:4175920-4176213 [Salmonella sp. A39]
INNDYPLNTLNQLRPLLIGFRKANGLTQKDLSERLGVTQQTYSRLEANPASASIERLFKVFSILGVKISFSSATTSSERK
QTEEMLKSNSPARQEDW

Download         Length: 294 bp

>AT218174 NZ_CP115668:499191-499442 [Cutibacterium sp. CBA3108]
ATGCGAACGACGTTAACGCTTGACCCTGATGTGACCGAGCTCCTTGAGCGCGAGATGGCTGAGCGTCATGTGTCGTTTAA
ACGCGTCGTCAACGATGCCTTGCGCCGCGGCTTGGGTAGTACCCAGAATGTGGATTTCACTTTCCCCAGCTTTAACTTGG
GGGCCGCGCGAGTCGATCTGACGCATGCCGCGAGGTTGGCTGCCGAGCTTGAGGACGATGCCCTCGCTGAGAAGCTTTCC
CAGGGTCGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3T0VBU1

Antitoxin

Source ID Structure
AlphaFold DB A0A5Z6V2D1

References