Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3505400..3506020 Replicon chromosome
Accession NZ_CP084194
Organism Salmonella sp. A39

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag LDO68_RS17360 Protein ID WP_001280991.1
Coordinates 3505802..3506020 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag LDO68_RS17355 Protein ID WP_000344807.1
Coordinates 3505400..3505774 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS17345 (3500539) 3500539..3501732 + 1194 WP_001039202.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
LDO68_RS17350 (3501755) 3501755..3504904 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
LDO68_RS17355 (3505400) 3505400..3505774 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
LDO68_RS17360 (3505802) 3505802..3506020 + 219 WP_001280991.1 HHA domain-containing protein Toxin
LDO68_RS17365 (3506199) 3506199..3506750 + 552 WP_001278792.1 maltose O-acetyltransferase -
LDO68_RS17370 (3506867) 3506867..3507337 + 471 WP_000136181.1 YlaC family protein -
LDO68_RS17375 (3507393) 3507393..3507533 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
LDO68_RS17380 (3507539) 3507539..3507799 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
LDO68_RS17385 (3508024) 3508024..3509574 + 1551 WP_000213139.1 EAL domain-containing protein -
LDO68_RS17395 (3509805) 3509805..3510194 + 390 WP_000961285.1 MGMT family protein -
LDO68_RS17400 (3510227) 3510227..3510796 - 570 WP_000779803.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T218169 WP_001280991.1 NZ_CP084194:3505802-3506020 [Salmonella sp. A39]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T218169 NZ_CP115665:c1451454-1450987 [Pseudomonas putida]
ATGAGTGATGCGAGCAGGAAGCCTCTGGTTATTCATGGATGGACTGTAATTGCCCACCCGCTGTTCCTGGCCAAACTGGA
CGCGCTAAGCGCTCAAGTCGAGGCTCAACGGGACAAAGACCCAACGGGTTATACGAAAAGAAATACCTTTAAAAGGCTGG
CCGCCATCCGGCGGTTGGCGTTCGATGTAATCCCTCAAGACCCGACCAAACCCGAATACCGGCAAGGGGCAACACTTGGC
GGTGACCACAAGCACTGGTTCAGAGCAAAGTTCTTCCAGCAGTACCGGTTGTTCTTCCGCTACCACACCCCCAGCAGGAT
CATCGTGCTGGCCTGGATCAATGACGAGTCGAGCAAGCGGGCCTATGAAAGTAGCGACGATGCTTACAAGGTCTTTCAAA
AGATGTTGCATAGCGGCAACCCACCGGACGATTGGGACCAGTTGCTGCAAGAGGCTGCCGCAGATTGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT218169 WP_000344807.1 NZ_CP084194:3505400-3505774 [Salmonella sp. A39]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT218169 NZ_CP115665:c1451777-1451451 [Pseudomonas putida]
ATGGCTGCCACCTTCGACGTCGAGTCCACGCTGACCGATCGCTATCAAACCACTGTTCCCGAAACGGTGCGGCGCGCCTT
GGGCTTGAAAAAACGTGACAAGATCCATTACTCGATTCGCCCCGACGGTGGGGTGATACTCACCCGCGCAGAGGCAACCG
AGGACGATCCGGTACTGGGCAAATTTCTGGATTTCCTGGCACACGATATCGCTACCAACCCTCAACGGCTGCAGGTTGTC
GATGCTGGCCTCATCGCGCGCCTCGACAAGCTTGTCGGCGACGCGGAGGTCGACCTGGATCAACCTCTGTCGGCGGACGA
TGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References