Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 996202..997016 Replicon chromosome
Accession NZ_CP084194
Organism Salmonella sp. A39

Toxin (Protein)


Gene name TacT3 Uniprot ID Q57KM2
Locus tag LDO68_RS04760 Protein ID WP_000971655.1
Coordinates 996202..996729 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID E8XL32
Locus tag LDO68_RS04765 Protein ID WP_000855692.1
Coordinates 996726..997016 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LDO68_RS04740 (991502) 991502..994069 - 2568 WP_001005807.1 DNA mismatch repair protein MutS -
LDO68_RS04745 (994228) 994228..994749 + 522 WP_000858988.1 hypothetical protein -
LDO68_RS04750 (994921) 994921..995577 - 657 WP_000420452.1 protein-serine/threonine phosphatase -
LDO68_RS04755 (995924) 995924..996129 + 206 Protein_932 IS5/IS1182 family transposase -
LDO68_RS04760 (996202) 996202..996729 - 528 WP_000971655.1 GNAT family N-acetyltransferase Toxin
LDO68_RS04765 (996726) 996726..997016 - 291 WP_000855692.1 DUF1778 domain-containing protein Antitoxin
LDO68_RS04770 (997286) 997286..997464 - 179 Protein_935 IS3 family transposase -
LDO68_RS04775 (997705) 997705..998031 + 327 WP_000393302.1 hypothetical protein -
LDO68_RS04780 (998304) 998304..998651 - 348 WP_001669174.1 DUF1493 family protein -
LDO68_RS04785 (998636) 998636..999085 - 450 WP_000381610.1 membrane protein -
LDO68_RS04790 (999516) 999516..999959 - 444 WP_000715092.1 SPI-1 type III secretion system invasion lipoprotein InvH -
LDO68_RS04795 (1000416) 1000416..1001066 + 651 WP_001674874.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 995953..1006379 10426
- flank IS/Tn - - 995953..996129 176


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19069.91 Da        Isoelectric Point: 9.6420

>T218159 WP_000971655.1 NZ_CP084194:c996729-996202 [Salmonella sp. A39]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T218159 NZ_CP115661:c4560512-4560216 [Pseudomonas putida]
ATGGAAAAGAGAATGCCTCATTGCCCGCTGGAGCGGGTAAAAGCCCTGGCTGCGGCAAGGCGAATCCGCCCTACGGGTGC
TGCATTGAAAGGCGCCAAGGCGCTGGGAATGGATTTTCCGGGCATGCTTGAGGTGATCACCAGCTTGAAGCGCACTGATT
TCTACAAGAGCATGACCAGCCATATTGACCACCGGGTTTGGCAGGATGTGTATCGCCCGCTTACAGCAATTGGGTACGTT
TATTTGAAATTGTCCGTGGTAGACGACGTGCTCATCGTGTCTTTCAAGGAGTTGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10678.57 Da        Isoelectric Point: 8.5779

>AT218159 WP_000855692.1 NZ_CP084194:c997016-996726 [Salmonella sp. A39]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNILPVAQKIVDAAERVYLTERDTKMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT218159 NZ_CP115661:c4560213-4559812 [Pseudomonas putida]
ATGAGATGTCCAATATGCGGCGGCTCGGAGCTTGCACCTGACATTCAGGGCATGCCCTATAGCTACAAAGGCGAGATGAC
AGTGATTCCTGAGGTAAGTGGCGATTACTGCTCCGCATGTGGTGAATGTGTACTGAGTCATGATGAAGCCATGCGCGTCA
GTCACTTGATGACGGCATTCGAGCGCCAGGTCAACGCAAATGTTGTGGATCCTTCCTTTATTGCCTCCATACGCAGAAAG
TTCGACCTCGACCAGCGTGAAGCGGGGGAAATCTTCGGTGGTGGGGTCAATGCGTTCTCCCGTTATGAAAACGGCAAGAC
CACCCCGCCAGTGGCGTTGGTGAAACTGCTCAAGCTGCTGGATCGCCATCCAGAACTCTTTGAGGAAGTGCGTACTGCCT
GA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6G96
PDB 7AK9

Antitoxin

Source ID Structure
PDB 7AK9
AlphaFold DB A0A625WHV3

References