Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 3553400..3554976 Replicon chromosome
Accession NZ_CP084031
Organism Aeromonas caviae strain K433

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag LCG53_RS16660 Protein ID WP_113068876.1
Coordinates 3553654..3554976 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag LCG53_RS16655 Protein ID WP_113068875.1
Coordinates 3553400..3553654 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCG53_RS16640 (LCG53_16640) 3549193..3549194 - 2 WP_225159511.1 IS5 family transposase -
LCG53_RS16645 (LCG53_16645) 3549707..3551428 + 1722 WP_113068873.1 AAA family ATPase -
LCG53_RS16650 (LCG53_16650) 3551431..3553056 + 1626 WP_113068874.1 ATP-dependent helicase -
LCG53_RS16655 (LCG53_16655) 3553400..3553654 + 255 WP_113068875.1 helix-turn-helix domain-containing protein Antitoxin
LCG53_RS16660 (LCG53_16660) 3553654..3554976 + 1323 WP_113068876.1 type II toxin-antitoxin system HipA family toxin Toxin
LCG53_RS16665 (LCG53_16665) 3555401..3556870 - 1470 WP_113068877.1 hypothetical protein -
LCG53_RS16670 (LCG53_16670) 3556815..3559379 - 2565 WP_113068878.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3548131..3564708 16577
- flank IS/Tn - - 3548678..3549310 632


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-104)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49530.09 Da        Isoelectric Point: 8.0907

>T217987 WP_113068876.1 NZ_CP084031:3553654-3554976 [Aeromonas caviae]
MANLWVYMNGYRVGTFTMTTSGAHQFQYDESWVTLPGSRPISLSMPLRQQCYRGDEPYNFFGNLLPDNLEVKNRVVARYQ
ANSTQSFDLLSCIGQDCVGALQLVAQGAPTPDVKRIECKPLSDAELEHILTSYQQGIPLGMVREVEDFRISIAGAQEKTA
LLYRDNRWYLPSAATPTTHIIKLPIGKIESHSYSIDLSQSVENEYLCTLIAKEFGLPVPHCFIMQVGKIKALAVERFDRR
YAADRSWIMRLPQEDFCQVLNVPSVRKYESHGGPSIADIMTTLLGSATPEQDRYLFMKSQVLFWLLAATDGHAKNFSVFI
EPGGSFRLTPFYDILSMYPAFGGRGLHPRDAKLAMGLTASKGKIYAIDHIFPCHFYRTAKAVGFEQAKMKRIIAEFIGNL
DMVISNVRAKLPDTFPPRITESILKGLTTRIQRLDLSSIE

Download         Length: 1323 bp

>T217987 NZ_CP115150:1686618-1687028 [Enterobacter hormaechei subsp. xiangfangensis]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCACAGTGGATGTCCTTACTGCTCCACGGTCTGGTCGCGGC
AATGGTGTTATTGGTGCCGTGGCCGCTAAGCTATACCCCTCTGTGGCTGCTTTTGCTGTCGTTTGTGGTGTTTGATAGCG
TGCGCAGCCAGCGTCGAATCAACGCCCGTCAGGGTGAAATTAAGCTGCTGATGGATTCTCGCCTGCGCTGGCAGGGAAAA
GAGTGGGAAATGATAGGGACGCCGTGGATGCTCAACACCGGGATGATGCTACGGCTGCGTCGGGTCGAGGATAACCGTCG
CCAGCACCTGTGGCTGGCCGCAGACAGTATGGATCCCGCGGAGTGGCGGGATCTGCGCCGGCTAATCGTGCAACAGCCAA
CGCAGGAATAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9437.77 Da        Isoelectric Point: 8.4810

>AT217987 WP_113068875.1 NZ_CP084031:3553400-3553654 [Aeromonas caviae]
MKVTSAKQLSAYLKDARLLQKYSQGKVADKVGIRQDTVSNFELNPESTKLDTLFKILAALELSLDIKPRTDPPDSPSSGW
KEEW

Download         Length: 255 bp

>AT217987 NZ_CP115150:1686371-1686637 [Enterobacter hormaechei subsp. xiangfangensis]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATCTCCATCATGCCTTT
CTTCGAGTATGAGTACGACAGCTTAAGCGATGACGATAAGCGCCTGTTTGTCCGTCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAATCACGGCAAGCCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CAGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References