Detailed information of TA system TA217986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1597380..1598976
• Replicon: chromosome
• Accession: NZ_CP084031
• Organism: Aeromonas caviae strain K433

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: LCG53_RS07850
• Protein ID: WP_201985066.1
• Coordinates: 1597380..1598696 (-)
• Length: 439 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LCG53_RS07855
• Protein ID: WP_201985067.1
• Coordinates: 1598680..1598976 (-)
• Length: 99 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCG53_RS07825 (LCG53_07825)	1592498..1593472	-	975	WP_041213220.1	taurine ABC transporter substrate-binding protein	-
LCG53_RS07830 (LCG53_07830)	1593761..1594864	-	1104	WP_201985084.1	YdcF family protein	-
LCG53_RS07835 (LCG53_07835)	1595014..1595907	-	894	WP_201985064.1	LysR family transcriptional regulator	-
LCG53_RS07840 (LCG53_07840)	1596008..1596766	+	759	WP_201985065.1	DMT family transporter	-
LCG53_RS07845 (LCG53_07845)	1597039..1597281	-	243	WP_005302916.1	DUF3297 family protein	-
LCG53_RS07850 (LCG53_07850)	1597380..1598696	-	1317	WP_201985066.1	HipA domain-containing protein	Toxin
LCG53_RS07855 (LCG53_07855)	1598680..1598976	-	297	WP_201985067.1	helix-turn-helix domain-containing protein	Antitoxin
LCG53_RS07860 (LCG53_07860)	1599343..1600173	-	831	WP_201985068.1	hypothetical protein	-
LCG53_RS07865 (LCG53_07865)	1600345..1601691	-	1347	WP_201985069.1	hypothetical protein	-
LCG53_RS07870 (LCG53_07870)	1601876..1602682	-	807	WP_201985070.1	tryptophan synthase subunit alpha	-
LCG53_RS07875 (LCG53_07875)	1602679..1603872	-	1194	WP_041213214.1	tryptophan synthase subunit beta	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (147-390)

Antitoxin

• Cro/C1-type helix-turn-helix domain (20-73)

Sequences

Toxin

Protein

• Length: 439 a.a.
• Molecular weight: 49327.54 Da
• Isoelectric Point: 6.5021

>T217986 WP_201985066.1 NZ_CP084031:c1598696-1597380 [Aeromonas caviae]
MMGGSEHHRLELRLGNQLIGHLEYDSSRDAFQLGYTPEWQARGFPLSPPLALDGSASSAQIRAYLGNLLPENRGLEHLIE
ALSVSRSNLFALIHGIGRDVSGAVTFTLPAEPDVPTHFRPITPKELLLRLDQPEIWPLEVWDGRPRLSVAGVQAKLNLLR
LEGTLGFGEGELCSTHLLKFEHHPHLVINEFVTMRLAALLGMPVARVELHRVGQGDKSHRSLLVERFDRRLDEDGLRVRR
RHMIDACQGLGFPVARKYERNFGDGRDVAHIREGVSLPRLFSLSALCVNPAQARLDMLQWLLFNLCVNNHDAHGKNYSFF
VSKAGLMPTPWYDLVNVGLYPEFNQHLAMAIGDEFAPEAVNAWQLLEMAEACELPKRLLQQTLHKMASDILHQLDAAIAL
VETDNPAELAYLARYRDDVEHRCHHFQAQATLLPELQL

Nucleotide

• Length: 1317 bp

>T217986 NZ_CP115150:1517044-1517385 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAAAACTCTACCTGCTATAATTTCGCGGGCGGCGAAGCCCTGTCTGTCGCCCGTTGCAGTCTGGCAAATGCTACTTAC
ACGCCTGCTGGAAAAACACTATGGTCTGACCCTGAACGATACGCCGTTCTGTGATGAAACCGTTATACAGGAACATATCG
ATGCCGGTATTACGCTGGCTGATGCCGTTAATTTTCTGGTGGAAAAATACGGACTGGTTCGTATCGACAGGAATGGATTT
GTCTGGCAGGAACAATCACCTTATCTTCGGGCCGTTGATATTCTGCGAGCGCGGCAGGCAACTGGCTTATTGCGACAAAG
CCGTAACAACGCAATACGTTGA

Antitoxin

Protein

• Length: 99 a.a.
• Molecular weight: 10477.19 Da
• Isoelectric Point: 9.0951

>AT217986 WP_201985067.1 NZ_CP084031:c1598976-1598680 [Aeromonas caviae]
MMADASLQTGPKALDPASLGLAIRERRKAARMTQEVTASLCGISKKTLIKIEKGGDVYLSTLLQVMKALGLRLQLVQEMG
SQVASGNSQPEVGDDGWF

Nucleotide

• Length: 297 bp

>AT217986 NZ_CP115150:1516706-1517023 [Enterobacter hormaechei subsp. xiangfangensis]
ATGAGCAACATTACATGGGGCCTGCAGCGGGATACCACGCCGCGTCTGGGAGCCCGTCTGGTACAGGAGGGGAACCAACT
GCATTATCTGGCTGACCGGGCCAGTATCACCGGTAAATTCAGTGACGCCGAATGCCGGAAGCTGGATGAAACATTCCCGT
ACTTTATCAGCCAGATGGAATCGATGCTGATCACTGGTGAAATGAATCCTCGCCATGCCCACTGTGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACCCTTGGCAGTTGCGGCTACGTATACATCGCCGTTTACCCCATCCAACGATAA