Detailed information of TA system TA217919

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2354894..2355416
• Replicon: chromosome
• Accession: NZ_CP084001
• Organism: Salmonella sp. A7

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A5J1ICX1
• Locus tag: LCS67_RS11515
• Protein ID: WP_000221344.1
• Coordinates: 2355132..2355416 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: LCS67_RS11510
• Protein ID: WP_000885424.1
• Coordinates: 2354894..2355142 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LCS67_RS11485 (2351285)	2351285..2352265	-	981	WP_080183699.1	nitronate monooxygenase	-
LCS67_RS11490 (2352439)	2352439..2353347	-	909	WP_001176637.1	LysR family transcriptional regulator	-
LCS67_RS11495 (2353759)	2353759..2353929	+	171	WP_000415762.1	DUF29 family protein	-
LCS67_RS11500 (2354205)	2354205..2354537	-	333	WP_000253078.1	DUF1493 family protein	-
LCS67_RS11505 (2354623)	2354623..2354742	-	120	Protein_2248	type II and III secretion system	-
LCS67_RS11510 (2354894)	2354894..2355142	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LCS67_RS11515 (2355132)	2355132..2355416	+	285	WP_000221344.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LCS67_RS11520 (2355588)	2355588..2355977	+	390	WP_000194089.1	RidA family protein	-
LCS67_RS11525 (2356035)	2356035..2357108	-	1074	WP_000954684.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
LCS67_RS11530 (2357301)	2357301..2357789	-	489	WP_001293634.1	MarR family winged helix-turn-helix transcriptional regulator	-
LCS67_RS11535 (2357834)	2357834..2359342	+	1509	WP_000199405.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2353987..2362199	8212

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11015.73 Da
• Isoelectric Point: 10.5388

>T217919 WP_000221344.1 NZ_CP084001:2355132-2355416 [Salmonella sp. A7]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Nucleotide

• Length: 285 bp

>T217919 NZ_CP114894:2640279-2640743 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT217919 WP_000885424.1 NZ_CP084001:2354894-2355142 [Salmonella sp. A7]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT217919 NZ_CP114894:2639944-2640279 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Structures

Toxin

• AlphaFold DB: A0A5J1ICX1

Antitoxin

• AlphaFold DB: A0A5I0WPN5