Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2354894..2355416 Replicon chromosome
Accession NZ_CP084001
Organism Salmonella sp. A7

Toxin (Protein)


Gene name stbE Uniprot ID A0A5J1ICX1
Locus tag LCS67_RS11515 Protein ID WP_000221344.1
Coordinates 2355132..2355416 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag LCS67_RS11510 Protein ID WP_000885424.1
Coordinates 2354894..2355142 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCS67_RS11485 (2351285) 2351285..2352265 - 981 WP_080183699.1 nitronate monooxygenase -
LCS67_RS11490 (2352439) 2352439..2353347 - 909 WP_001176637.1 LysR family transcriptional regulator -
LCS67_RS11495 (2353759) 2353759..2353929 + 171 WP_000415762.1 DUF29 family protein -
LCS67_RS11500 (2354205) 2354205..2354537 - 333 WP_000253078.1 DUF1493 family protein -
LCS67_RS11505 (2354623) 2354623..2354742 - 120 Protein_2248 type II and III secretion system -
LCS67_RS11510 (2354894) 2354894..2355142 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
LCS67_RS11515 (2355132) 2355132..2355416 + 285 WP_000221344.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCS67_RS11520 (2355588) 2355588..2355977 + 390 WP_000194089.1 RidA family protein -
LCS67_RS11525 (2356035) 2356035..2357108 - 1074 WP_000954684.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
LCS67_RS11530 (2357301) 2357301..2357789 - 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
LCS67_RS11535 (2357834) 2357834..2359342 + 1509 WP_000199405.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2353987..2362199 8212


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11015.73 Da        Isoelectric Point: 10.5388

>T217919 WP_000221344.1 NZ_CP084001:2355132-2355416 [Salmonella sp. A7]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTQHRS

Download         Length: 285 bp

>T217919 NZ_CP114894:2640279-2640743 [Escherichia coli]
ATGGATTTTCCACAAAGGGTTAATGGTTGGGCGCTATATGCTCATCCCTGTTTTCAGGAAACCTACGACGCTTTAGTTGC
CGAAGTCGAGACATTAAAGGGAAAAGATCCTGAAAATTATCAGAGAAAAGCCGCCACAAAGTTATTGGCGGTAGTCCATA
AAGTGATTGAGGAGCATATCACGGTCAATCCATCATCACCGGCATTCCGTCATGGCAAGTCGTTAGGCTCTGGGAAAAAT
AAAGACTGGTCACGGGTAAAATTTGGTGCTGGTCGTTATCGTCTCTTCTTTCGTTATAGTGAAAAAGAGAAAGTCATCAT
TCTGGGATGGATGAACGATGAAAACACTCTGCGCACCTACGGTAAAAAAACAGATGCCTATACCGTATTCAGCAAAATGT
TAAAAAGAGGACATCCTCCTGCCGACTGGGAAACCCTCACCCGAGAAACAGAAGAAACCCATTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT217919 WP_000885424.1 NZ_CP084001:2354894-2355142 [Salmonella sp. A7]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT217919 NZ_CP114894:2639944-2640279 [Escherichia coli]
ATGCCCGCTAATGCTCGCTCTCACGCTGTACTGACCACTGAATCAAAGGTCACGATACGCGGACAAACAACTATCCCCGC
GCCAGTGCGTGAGGCCTTAAAACTGAAGCCAGGCCAGGACAGCATTCATTACGAAATTCTGCCTGGTGGGCAAGTATTTA
TGTGCCGACTGGGAGATGAACAGGAGGATCATACTATGAATGCATTTTTGCGTTTTCTGGATGCAGATATCCAGAACAAC
CCGCAAAAAACTCGTCCATTCAACATTCAACAAGGAAAGAAACTTGTCGCTGGCATGGACGTCAACATTGATGATGAGAT
TGGCGACGACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5J1ICX1

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References