Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symER/SymE(toxin)
Location 3903011..3903423 Replicon chromosome
Accession NZ_CP083990
Organism Escherichia coli strain EC2648-Vir2

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag LCH23_RS19030 Protein ID WP_000132601.1
Coordinates 3903082..3903423 (+) Length 114 a.a.

Antitoxin (RNA)


Gene name symR
Locus tag -
Coordinates 3903011..3903087 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCH23_RS19020 (3899874) 3899874..3901463 + 1590 WP_001063204.1 type I restriction-modification system methyltransferase -
LCH23_RS19025 (3901460) 3901460..3902854 + 1395 WP_072647344.1 type I restriction-modification system specificity subunit -
- (3903011) 3903011..3903087 - 77 NuclAT_14 - Antitoxin
- (3903011) 3903011..3903087 - 77 NuclAT_14 - Antitoxin
- (3903011) 3903011..3903087 - 77 NuclAT_14 - Antitoxin
- (3903011) 3903011..3903087 - 77 NuclAT_14 - Antitoxin
- (3903011) 3903011..3903087 - 77 NuclAT_15 - Antitoxin
- (3903011) 3903011..3903087 - 77 NuclAT_15 - Antitoxin
- (3903011) 3903011..3903087 - 77 NuclAT_15 - Antitoxin
- (3903011) 3903011..3903087 - 77 NuclAT_15 - Antitoxin
LCH23_RS19030 (3903082) 3903082..3903423 + 342 WP_000132601.1 endoribonuclease SymE Toxin
LCH23_RS19035 (3903585) 3903585..3904964 + 1380 WP_072647343.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
LCH23_RS19040 (3904964) 3904964..3906010 + 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T217901 WP_000132601.1 NZ_CP083990:3903082-3903423 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T217901 NZ_CP114893:3895198-3895305 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 77 bp

>AT217901 NZ_CP083990:c3903087-3903011 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References