Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacT-ataR/DUF1778(antitoxin)
Location 5542041..5542801 Replicon chromosome
Accession NZ_CP083951
Organism Mesorhizobium sp. B2-8-5

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag FJ430_RS27500 Protein ID WP_140705463.1
Coordinates 5542322..5542801 (+) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID -
Locus tag FJ430_RS27495 Protein ID WP_140705465.1
Coordinates 5542041..5542322 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
FJ430_RS27475 (FJ430_27475) 5538842..5539072 + 231 WP_140705470.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
FJ430_RS27480 (FJ430_27480) 5539083..5539565 - 483 WP_140705469.1 transcription elongation factor GreA -
FJ430_RS27485 (FJ430_27485) 5539670..5541046 + 1377 WP_140705467.1 TIGR03808 family TAT-translocated repetitive protein -
FJ430_RS27490 (FJ430_27490) 5541043..5541855 - 813 WP_140705538.1 methyltransferase domain-containing protein -
FJ430_RS27495 (FJ430_27495) 5542041..5542322 + 282 WP_140705465.1 DUF1778 domain-containing protein Antitoxin
FJ430_RS27500 (FJ430_27500) 5542322..5542801 + 480 WP_140705463.1 GNAT family N-acetyltransferase Toxin
FJ430_RS27505 (FJ430_27505) 5542794..5543798 - 1005 WP_140705461.1 asparaginase -
FJ430_RS27510 (FJ430_27510) 5543851..5545017 - 1167 WP_140705459.1 acetyl-CoA acetyltransferase -
FJ430_RS27515 (FJ430_27515) 5545206..5545796 + 591 WP_140705457.1 transcriptional regulator BetI -
FJ430_RS27520 (FJ430_27520) 5545793..5547322 + 1530 WP_140705455.1 choline-sulfatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(41-142)

Antitoxin

Vibrio phage ICP1, Orf50

(14-77)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 16953.42 Da        Isoelectric Point: 8.8983

>T217847 WP_140705463.1 NZ_CP083951:5542322-5542801 [Mesorhizobium sp. B2-8-5]
MLSAPVLLADSHELDFFQSGTDSLDQWLRRRARANQVSGASRTYVIAEGTRVVGYYCLSSGGLDLVDAPGSIRRNMPDPV
PMAVLGRLAVDAGRQGKGLGVALLQDAVLRTGQAAAILGIRGLLVHAISDEAKAFYEHYGFQASPKNPMTLVLSLRTAS

Download         Length: 480 bp

>T217847 NZ_CP114891:3126420-3126698 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10709.18 Da        Isoelectric Point: 8.5141

>AT217847 WP_140705465.1 NZ_CP083951:5542041-5542322 [Mesorhizobium sp. B2-8-5]
MATKNQDRHAKPVNLRIREDVRILIDRAAKIRGKTRSDFMIDAAYRAAEDTLLDQTLVKVDAESYQHYLDILDQPPSGEG
FARLMNAPKPWRD

Download         Length: 282 bp

>AT217847 NZ_CP114891:3126157-3126417 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References