Detailed information of TA system TA021772

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2506647..2507185
• Replicon: chromosome
• Accession: NC_008571
• Organism: Gramella forsetii KT0803

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0M3X8
• Locus tag: GFO_RS11115
• Protein ID: WP_011710226.1
• Coordinates: 2506886..2507185 (+)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0M3X7
• Locus tag: GFO_RS11110
• Protein ID: WP_011710225.1
• Coordinates: 2506647..2506889 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GFO_RS17550	2501774..2501944	+	171	WP_011710220.1	hypothetical protein	-
GFO_RS11090	2501944..2502753	+	810	WP_011710221.1	Cof-type HAD-IIB family hydrolase	-
GFO_RS11095	2502821..2504086	+	1266	WP_041250106.1	DUF819 family protein	-
GFO_RS11100	2504141..2504887	+	747	WP_011710223.1	DUF4369 domain-containing protein	-
GFO_RS11105	2505271..2506536	+	1266	WP_011710224.1	OFA family MFS transporter	-
GFO_RS11110	2506647..2506889	+	243	WP_011710225.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
GFO_RS11115	2506886..2507185	+	300	WP_011710226.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GFO_RS11125	2507535..2507801	-	267	WP_011710227.1	hypothetical protein	-
GFO_RS11130	2507865..2508317	-	453	WP_011710228.1	peroxiredoxin	-
GFO_RS11135	2508319..2508729	-	411	WP_011710229.1	6-carboxytetrahydropterin synthase	-
GFO_RS11140	2508726..2509244	-	519	WP_011710230.1	isopentenyl-diphosphate Delta-isomerase	-
GFO_RS11145	2509313..2510923	-	1611	WP_011710231.1	OmpA family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (4-70)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 12211.13 Da
• Isoelectric Point: 10.2255

>T21772 WP_011710226.1 NC_008571:2506886-2507185 [Gramella forsetii KT0803]
MSNDKYRISQKALEDLDKIWIYTFKKWSKVQADRYYNLIIEEIHFIADNFLTGKSAEQTRKNYRVTKIKSHLIFYRKDEN
QTVEIIRILHERMDIKRRL

Nucleotide

• Length: 300 bp

>T21772 NC_008571:2506886-2507185 [Gramella forsetii KT0803]
ATGAGTAACGATAAATATCGAATAAGTCAAAAGGCACTTGAAGATTTAGATAAAATTTGGATTTACACTTTTAAAAAATG
GTCTAAGGTACAAGCAGACAGATATTACAATTTAATAATTGAAGAAATTCATTTTATAGCAGATAATTTTTTGACAGGTA
AATCAGCCGAACAAACGCGAAAAAATTATCGAGTAACAAAAATAAAATCACATTTGATTTTTTACAGAAAAGATGAAAAT
CAAACCGTAGAAATCATTAGAATTCTCCACGAAAGAATGGATATAAAAAGACGTTTATAG

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9286.36 Da
• Isoelectric Point: 5.2092

>AT21772 WP_011710225.1 NC_008571:2506647-2506889 [Gramella forsetii KT0803]
MGKNTSISLGNHFEEFINEELKSGRYNSVSEIIRSALRLLESEERKEKELIKALEAGEQSGFVEDFDSKEHLKELHRQHL

Nucleotide

• Length: 243 bp

>AT21772 NC_008571:2506647-2506889 [Gramella forsetii KT0803]
ATGGGAAAAAACACCTCTATATCACTTGGAAATCATTTTGAAGAGTTTATTAATGAAGAATTAAAATCTGGAAGATATAA
CTCTGTAAGTGAAATAATTCGTTCTGCTTTAAGGTTATTAGAAAGTGAAGAAAGAAAAGAAAAAGAGCTTATTAAAGCTC
TAGAAGCAGGAGAACAAAGTGGATTTGTTGAAGATTTCGATTCTAAAGAACACTTAAAAGAATTGCACCGGCAACACTTA
TGA

Structures

Toxin

• AlphaFold DB: A0M3X8

Antitoxin

• AlphaFold DB: A0M3X7