Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 1124735..1125384 Replicon chromosome
Accession NZ_CP083857
Organism Enterobacter kobei strain 12379-yvys

Toxin (Protein)


Gene name higB Uniprot ID A0A2J0PLQ3
Locus tag LCD50_RS05300 Protein ID WP_014882864.1
Coordinates 1125022..1125384 (-) Length 121 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID A0A2W0GCS7
Locus tag LCD50_RS05295 Protein ID WP_014882863.1
Coordinates 1124735..1125034 (-) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD50_RS05285 (LCD50_05295) 1121160..1123133 + 1974 WP_023336850.1 PhoX family phosphatase -
LCD50_RS05290 (LCD50_05300) 1123236..1124624 + 1389 WP_014882862.1 phenylalanine transporter -
LCD50_RS05295 (LCD50_05305) 1124735..1125034 - 300 WP_014882863.1 helix-turn-helix transcriptional regulator Antitoxin
LCD50_RS05300 (LCD50_05310) 1125022..1125384 - 363 WP_014882864.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCD50_RS05305 (LCD50_05315) 1125590..1126825 + 1236 WP_023332295.1 MFS transporter -
LCD50_RS05310 (LCD50_05320) 1126841..1127866 + 1026 WP_032665301.1 sugar phosphate isomerase/epimerase -
LCD50_RS05315 (LCD50_05325) 1127859..1129001 + 1143 WP_023336852.1 Gfo/Idh/MocA family oxidoreductase -
LCD50_RS05320 (LCD50_05330) 1129077..1130048 + 972 WP_014882868.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(16-107)

Antitoxin

Cro/C1-type helix-turn-helix domain

(31-80)


Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 13952.92 Da        Isoelectric Point: 6.7114

>T217568 WP_014882864.1 NZ_CP083857:c1125384-1125022 [Enterobacter kobei]
MWNVETTDRFDQWYFEQTTALKEDVLAMMHILAEFGPTLGRPYVDTVKASAYANMKELRIQHAGNPIRAFFAFDPDRKAI
VLCAGNKTGCNQKRFYNEMITLADVEYSRHLADKEAIWQR

Download         Length: 363 bp

>T217568 NZ_CP114372:c821120-820725 [Aeromicrobium sp. HA]
GTGATCGTCGATACCTCGGCCGTCGTGGCGGTCATCAAGCGCGAGGCCGGGTGGGAGGCGATCGACCGCGCCCTCGCCGC
CGCCACGACGCCGCGCATGTCGGCGGGAACGCAGCTGGAGCTGGGCATCGTCGTCGACCAGGCACGCGACCCCGAACTGT
CGCGCCTCGTGGACGCGCTCCTGCGCGACTGGAGCGTGGAGATCGAGCCCGTGACGGCCGAGCACGCGCGGATCGCCCGC
GAGGCGTACCGCGACTACGGCCGCGGCTCGGGACACCGAGCGCGACTCAACTATGGGGACTGCTTCGCTTACGCGCTCGC
GAGCCAATCCGGAGAGCCTCTGCTGTACGTCGGCGACGACTTCGCCGCGACCGACCTCACTCCCGTCCTGGTCTGA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10860.61 Da        Isoelectric Point: 9.8627

>AT217568 WP_014882863.1 NZ_CP083857:c1125034-1124735 [Enterobacter kobei]
MATLKELMAQQSAESQERIAAKVDVIRRIVALNQLREELNISQTELAAAMGVKQPTVAKIEQPGNDPRLSTLKRYVSALG
GEMSIDVTLPNGKRIAFQI

Download         Length: 300 bp

>AT217568 NZ_CP114372:c821353-821117 [Aeromicrobium sp. HA]
ATGGCTCTCAACATCAAGAACGAGCGCGTGCATGCGCTTGCACGCGAGGTGGCTCAGCGCACCGGGCGTACCCAGACCAG
CGCGATCGAGTTCGCCCTGGAGAGACTGCTGGCCAACCTTGGTGACTCCTCTGCCGCCATCGCTCGGCGCCAGCGCATTG
AGCACGTCCAAGATCTCGCCGTGAACGCGGACCTCGACGCCGAGGACCTGTACGACGAGGCCGGACTCCCCCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2J0PLQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A2W0GCS7

References