Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 476612..477128 Replicon chromosome
Accession NZ_CP083857
Organism Enterobacter kobei strain 12379-yvys

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag LCD50_RS02270 Protein ID WP_213782898.1
Coordinates 476844..477128 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A8E1RL94
Locus tag LCD50_RS02265 Protein ID WP_023331889.1
Coordinates 476612..476854 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LCD50_RS02250 (LCD50_02255) 472707..473450 + 744 WP_023338953.1 KDGP aldolase family protein -
LCD50_RS02255 (LCD50_02260) 473468..474604 + 1137 WP_213782897.1 lactonase family protein -
LCD50_RS02260 (LCD50_02265) 474624..476534 + 1911 WP_247170682.1 PRD domain-containing protein -
LCD50_RS02265 (LCD50_02270) 476612..476854 + 243 WP_023331889.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
LCD50_RS02270 (LCD50_02275) 476844..477128 + 285 WP_213782898.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LCD50_RS02275 (LCD50_02280) 477132..477596 - 465 WP_023338956.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
LCD50_RS02280 (LCD50_02285) 477738..479876 - 2139 WP_014882293.1 anaerobic ribonucleoside-triphosphate reductase -
LCD50_RS02285 (LCD50_02290) 480246..480818 - 573 WP_014882294.1 PTS sugar transporter subunit IIA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10924.72 Da        Isoelectric Point: 10.1988

>T217566 WP_213782898.1 NZ_CP083857:476844-477128 [Enterobacter kobei]
MTYELVFDPRALKEWSKLGDTVKNQFKKKLADVLVNPRVESTRLHGLPDCYKIKLRSQGYRLVYQVQDDVVTVFVIAVGK
REKSAVYHDANKRL

Download         Length: 285 bp

>T217566 NZ_CP114365:c26226-25978 [Klebsiella variicola]
ATGGGGAAAACAGATAAGCTACTGGCAAAGTTTTTAAACAGTAAAAAAACGTTTGAATGGGATGAACTGGTCGTTTTGTT
TTCCTCTTTGGGATATGTCAAAAAGGAAATGCAGGGGTCAAGAGTGCGGTTTTTCAATGCTGAAATCAATCACACCATAT
TAATGCATCGTCCACATCCGGAAAGTTATATCAAAGGTGGTACGCTGAAAGCAATTAAACAGAATCTGAAAGAGGCTGGA
TTATTATGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9030.41 Da        Isoelectric Point: 4.7719

>AT217566 WP_023331889.1 NZ_CP083857:476612-476854 [Enterobacter kobei]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDELIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT217566 NZ_CP114365:c25981-25634 [Klebsiella variicola]
ATGAAACATTTAAAATATAAAGGATATTTAGGCACGGTTGAACCCGATTTTGAAAATAATGTCCTGTATGGAAAACTGGC
GTTTATTCGGGACCTGGTAACTTATGAGGCTTCTACATTAGCTGAACTGGAACAGGAGTTTAAAACATCTGTTGATCTGT
ATTTACAGTCTTGTGTGGAGGATGGAAAGGAACCTGATACCCCGTTTAAAGGCGTGTTTAACGTCAGGCTTGATCCAGAA
CTGCATCGTCGGGTAGCAGAAATGGCGATGGAAGAAGATTTATCGTTGAATGCCTTTGTTAATAAGGCTCTGGAAAAAGA
AGTCAGCAATCATCGCGCAGGGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References