Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 2196415..2196977 Replicon chromosome
Accession NZ_CP083754
Organism Serratia marcescens strain YL4

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag LBP97_RS10425 Protein ID WP_025303801.1
Coordinates 2196415..2196771 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag LBP97_RS10430 Protein ID WP_004936539.1
Coordinates 2196768..2196977 (-) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LBP97_RS10405 (LBP97_10415) 2192151..2192948 - 798 WP_025303797.1 TonB family protein -
LBP97_RS10410 (LBP97_10420) 2193051..2193890 - 840 WP_167325036.1 ChaN family lipoprotein -
LBP97_RS10415 (LBP97_10425) 2194068..2195477 + 1410 WP_025303799.1 S-methylmethionine permease -
LBP97_RS10420 (LBP97_10430) 2195467..2196405 + 939 WP_238969558.1 homocysteine S-methyltransferase -
LBP97_RS10425 (LBP97_10435) 2196415..2196771 - 357 WP_025303801.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
LBP97_RS10430 (LBP97_10440) 2196768..2196977 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
LBP97_RS10435 (LBP97_10445) 2197087..2199367 - 2281 Protein_2053 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
LBP97_RS10440 (LBP97_10450) 2199582..2199755 - 174 WP_049205380.1 hypothetical protein -
LBP97_RS10445 (LBP97_10455) 2199736..2200116 - 381 WP_049209349.1 DUF2570 family protein -
LBP97_RS10450 (LBP97_10460) 2200113..2200514 - 402 WP_025303803.1 M15 family metallopeptidase -
LBP97_RS10455 (LBP97_10465) 2200504..2200830 - 327 WP_033643982.1 phage holin, lambda family -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-79)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 119 a.a.        Molecular weight: 13163.93 Da        Isoelectric Point: 4.9139

>T217254 WP_025303801.1 NZ_CP083754:c2196771-2196415 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHGRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T217254 NZ_CP114128:286297-286527 [Escherichia coli]
CTGGATCAGCTATTTAAATCACCTTTACCTCAAGGAATCAAATGGACTGATATAGAATCTCTGGTTAAAGCGTTAGGCGG
AGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGTTCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGT
CGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTGCGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT217254 WP_004936539.1 NZ_CP083754:c2196977-2196768 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT217254 NZ_CP114128:286524-286883 [Escherichia coli]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCAGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGTATTCAGGGGCTGCAAAAAGAAGGAG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAAACC
TTTACGTTACGTTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTTAATACCTA
TATTATTGAAACACTGAATGAGCGTTTGAATCATTTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References