217188

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2407758..2408280 Replicon chromosome
Accession NZ_CP083731
Organism Salmonella sp. A29-2

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag K8W53_RS11720 Protein ID WP_000221345.1
Coordinates 2407996..2408280 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag K8W53_RS11715 Protein ID WP_000885424.1
Coordinates 2407758..2408006 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8W53_RS11685 (2403908) 2403908..2404192 - 285 Protein_2281 LysR family transcriptional regulator -
K8W53_RS11690 (2404594) 2404594..2404782 + 189 WP_001276021.1 DUF29 family protein -
K8W53_RS11695 (2405148) 2405148..2405887 + 740 Protein_2283 hypothetical protein -
K8W53_RS11700 (2405889) 2405889..2406797 - 909 WP_077906523.1 hypothetical protein -
K8W53_RS11705 (2407070) 2407070..2407401 - 332 Protein_2285 DUF1493 family protein -
K8W53_RS11710 (2407487) 2407487..2407606 - 120 Protein_2286 type II and III secretion system -
K8W53_RS11715 (2407758) 2407758..2408006 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K8W53_RS11720 (2407996) 2407996..2408280 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K8W53_RS11725 (2408451) 2408451..2408840 + 390 WP_000194089.1 RidA family protein -
K8W53_RS11730 (2408892) 2408892..2409971 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
K8W53_RS11735 (2410164) 2410164..2410652 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
K8W53_RS11740 (2410697) 2410697..2412205 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2398278..2415062 16784


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T217188 WP_000221345.1 NZ_CP083731:2407996-2408280 [Salmonella sp. A29-2]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T217188 NZ_CP113972:c2325707-2325453 [Alteromonas sp. 009811495]
ATGAAAGTTGTATCATTTACTGAAGCGAGAAATGGTCTTAAGAGTGTTCTGGATAGCGTAGTTAATGACGCGGATACTAC
CGTAATTACCAGACGTGATTCCGAAGACGCAGTTGTAATGTCGTTAGACTACTACAACAGCCTTATGGAGACCGTTCATC
TATTGCGCTCACCAGCCAATGCTGAACATTTAAACCACTCAATATCTCAATACAAACAGGGTCAATTAAAAACGAGAGAA
CTCTTAGATGACTGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT217188 WP_000885424.1 NZ_CP083731:2407758-2408006 [Salmonella sp. A29-2]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT217188 NZ_CP113972:c2325460-2325197 [Alteromonas sp. 009811495]
ATGACTGAACGCTTACTTTCCTGGACGGATGCAGCGTGGAGTGATTACGTTTATTGGCAAACTCAAGATAAGAAAACTCT
TAAACGGATAAACAAATTAATTGTGGAGACTAAGCGTTCACCATTCGAGGGGATAGGCAAACCTGAAGCATTGAAAGAGA
ATTTGAGTGGTTTCTGGTCACGTAGAATAGATGTAACTAATCGTCTGGTTTATGCAGTTGACGACAACGCTTTAATAATT
ATTTCATGCCGCTACCACTACTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References