Detailed information of TA system TA217059

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): txpA-SprF3/-
• Location: 2009140..2009439
• Replicon: chromosome
• Accession: NZ_CP083671
• Organism: Staphylococcus aureus strain HL25870

Toxin (Protein)

• Gene name: txpA
• Uniprot ID: Q2FWU9
• Locus tag: K3A99_RS09865
• Protein ID: WP_011447039.1
• Coordinates: 2009263..2009439 (-)
• Length: 59 a.a.

Antitoxin (RNA)

Gene name	SprF3
Locus tag	-
Coordinates	2009140..2009195 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K3A99_RS09825	2004471..2004731	+	261	WP_001791826.1	hypothetical protein	-
K3A99_RS09830	2004784..2005134	-	351	WP_000702263.1	complement inhibitor SCIN-A	-
K3A99_RS09835	2005819..2006268	+	450	WP_000727649.1	chemotaxis-inhibiting protein CHIPS	-
K3A99_RS09840	2006363..2006698	-	336	Protein_1900	SH3 domain-containing protein	-
K3A99_RS09845	2007348..2007839	-	492	WP_000919350.1	staphylokinase	-
K3A99_RS09850	2008030..2008785	-	756	WP_000861038.1	CHAP domain-containing protein	-
K3A99_RS09855	2008797..2009051	-	255	WP_000611512.1	phage holin	-
K3A99_RS09860	2009103..2009210	+	108	WP_001791821.1	hypothetical protein	-
-	2009132..2009271	+	140	NuclAT_0	-	-
-	2009132..2009271	+	140	NuclAT_0	-	-
-	2009132..2009271	+	140	NuclAT_0	-	-
-	2009132..2009271	+	140	NuclAT_0	-	-
-	2009140..2009195	+	56	-	-	Antitoxin
K3A99_RS09865	2009263..2009439	-	177	WP_011447039.1	type I toxin-antitoxin system toxin PepG1	Toxin
K3A99_RS09870	2009589..2009885	-	297	WP_000539688.1	DUF2951 domain-containing protein	-
K3A99_RS09875	2009943..2010230	-	288	WP_001040261.1	hypothetical protein	-
K3A99_RS09880	2010277..2010429	-	153	WP_001153681.1	hypothetical protein	-
K3A99_RS09885	2010419..2014204	-	3786	WP_000582165.1	phage tail spike protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	scn / chp / sak / hlb / groEL	2004784..2057204	52420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Small toxic protein BsrE-like (30-58)

Sequences

Toxin

Protein

• Length: 59 a.a.
• Molecular weight: 6849.45 Da
• Isoelectric Point: 10.6777

>T217059 WP_011447039.1 NZ_CP083671:c2009439-2009263 [Staphylococcus aureus]
MDRWWLSEYKEVVPMVALLKSLERRRLMITISTMLQFGLFLIALIGLVIKLIELSNKK

Nucleotide

• Length: 177 bp

>T217059 NZ_CP113784:c2468720-2468502 [Citrobacter freundii]
ATGTCCGATAAACCATTAACTAAAACAGATTATTTGATGCGCCTGCGACGTTGCCAGACAATTGATACGCTAGAGCGCGT
TATTGAAAAAAATAAATATGAATTGTCCGACAACGAACTGGCTGTATTTTACTCAGCAGCAGATCATCGCCTTGCTGAAT
TGACCATGAATAAGCTTTACGACAAGATTCCAACTTCTGTTTGGAAATTCATTCGCTAA

Antitoxin

Nucleotide

• Length: 56 bp

>AT217059 NZ_CP083671:2009140-2009195 [Staphylococcus aureus]
AAAAAGGGCAACATGCGCAAACATGTTACCCTAATGAGCCCGTTAAAAAGACGGTG

Structures

Toxin

• PDB: 7NS1

Antitoxin