Detailed information of TA system TA216967

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 2869087..2869345
• Replicon: chromosome
• Accession: NZ_CP083638
• Organism: Escherichia fergusonii strain FDAARGOS_1499

Toxin (Protein)

• Gene name: hokC
• Uniprot ID: S1NX00
• Locus tag: LA347_RS13760
• Protein ID: WP_000809168.1
• Coordinates: 2869193..2869345 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	sokC
Locus tag	-
Coordinates	2869087..2869144 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA347_RS13735	2864890..2865831	-	942	WP_000767329.1	bifunctional riboflavin kinase/FAD synthetase	-
LA347_RS13740	2865839..2866057	-	219	WP_012599853.1	DUF2575 family protein	-
LA347_RS13745	2866160..2866423	+	264	WP_001274021.1	30S ribosomal protein S20	-
LA347_RS13750	2866519..2867418	-	900	WP_000019049.1	transcriptional activator NhaR	-
LA347_RS13755	2867486..2868652	-	1167	WP_000681374.1	Na+/H+ antiporter NhaA	-
-	2869087..2869144	-	58	-	-	Antitoxin
LA347_RS13760	2869193..2869345	+	153	WP_000809168.1	type I toxin-antitoxin system toxin MokC	Toxin
LA347_RS13765	2869449..2870579	-	1131	WP_001118464.1	molecular chaperone DnaJ	-
LA347_RS13770	2870668..2872584	-	1917	WP_000516135.1	molecular chaperone DnaK	-
LA347_RS13775	2873092..2873658	+	567	WP_000528529.1	acetate uptake transporter	-
LA347_RS13780	2873692..2874279	-	588	WP_002431696.1	molybdopterin adenylyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5501.57 Da
• Isoelectric Point: 7.1312

>T216967 WP_000809168.1 NZ_CP083638:2869193-2869345 [Escherichia fergusonii]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Nucleotide

• Length: 153 bp

>T216967 NZ_CP113536:c2350890-2350606 [Salmonella enterica]
ATGACTTATAAGCTGGCATTTAACGAATCAGCACTAAAAGAGTGGAAAAAACTGGGTCATACCATACAGGAACAGTTTAA
AAAAAAGCTAAGGGAACGGCTTGAAAACCCTCGGGTTCCGGCTTCTCAATTACATGGAAGAAAGGATCAGTACAAAATTA
AGCTGCGTGGTGCAGGATACAGGCTGGTGTACAGCGTCGAAGATGAAATTATCACGGTAACTGTCATTGGTGTTGGAAAG
CGTGAAAATGATGCCGTCTACAAAATGACACGACACAGAAGCTAA

Antitoxin

Nucleotide

• Length: 58 bp

>AT216967 NZ_CP083638:c2869144-2869087 [Escherichia fergusonii]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Structures

Toxin

• AlphaFold DB: S1NX00

Antitoxin