Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 710214..710701 Replicon chromosome
Accession NZ_CP083637
Organism Gemella haemolysans strain FDAARGOS_1500

Toxin (Protein)


Gene name relE Uniprot ID C5NYE0
Locus tag LA340_RS03275 Protein ID WP_003145533.1
Coordinates 710438..710701 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C5NYD9
Locus tag LA340_RS03270 Protein ID WP_003144945.1
Coordinates 710214..710438 (+) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LA340_RS03260 (LA340_03260) 705343..707037 - 1695 WP_003145427.1 AIPR family protein -
LA340_RS03265 (LA340_03265) 707422..710004 + 2583 WP_003145411.1 ATP-dependent chaperone ClpB -
LA340_RS03270 (LA340_03270) 710214..710438 + 225 WP_003144945.1 DUF6290 family protein Antitoxin
LA340_RS03275 (LA340_03275) 710438..710701 + 264 WP_003145533.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
LA340_RS03280 (LA340_03280) 710745..711404 + 660 WP_003145163.1 hypothetical protein -
LA340_RS03285 (LA340_03285) 711484..712305 - 822 WP_003145294.1 lipoate--protein ligase family protein -
LA340_RS03290 (LA340_03290) 712477..713526 - 1050 WP_003144914.1 PTS sugar transporter subunit IIC -
LA340_RS03295 (LA340_03295) 713719..714363 + 645 WP_003145587.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-86)

Antitoxin

Protein of unknown function DUF6290

(1-72)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10464.27 Da        Isoelectric Point: 10.4227

>T216952 WP_003145533.1 NZ_CP083637:710438-710701 [Gemella haemolysans]
MYKIVFDEAIKKDLKKLDKQTLKILFSWIEKNLSNTDDPRGMGKALVGNKKGYWRYRIGDYRLITRIEDDRLIIIAINFK
HRREVYS

Download         Length: 264 bp

>T216952 NZ_CP113535:2143818-2143921 [Salmonella enterica]
GGCAAGGCGATTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 8644.78 Da        Isoelectric Point: 4.1532

>AT216952 WP_003144945.1 NZ_CP083637:710214-710438 [Gemella haemolysans]
MTTLTLRLNKEEEQIFNSISGLYGGKLSTTIKQLALEKIEDEYDLQLIKDFESREEKGEVTLIEFDDLKKEFDL

Download         Length: 225 bp

>AT216952 NZ_CP113535:c2143923-2143778 [Salmonella enterica]
ATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGC
ATTAATGCAGGCTAAATCGCCTTGCCCTTTAAGAATAGATGACGACGCCAGGTTTTCCAGTTTGCG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB C5NYE0

Antitoxin

Source ID Structure
AlphaFold DB C5NYD9

References