Detailed information of TA system TA216935

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): ypjF-yeeU/CbtA-CbeA
• Location: 3244605..3245161
• Replicon: chromosome
• Accession: NZ_CP083631
• Organism: Klebsiella quasipneumoniae strain FDAARGOS_1504

Toxin (Protein)

• Gene name: ypjF
• Uniprot ID: -
• Locus tag: LA339_RS15520
• Protein ID: WP_133295396.1
• Coordinates: 3244605..3244760 (-)
• Length: 52 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: LA339_RS15525
• Protein ID: WP_012543031.1
• Coordinates: 3244805..3245161 (-)
• Length: 119 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA339_RS15505 (3240906)	3240906..3241544	-	639	WP_032456938.1	HNH endonuclease	-
LA339_RS15510 (3241724)	3241724..3242593	+	870	WP_032456937.1	HNH endonuclease	-
LA339_RS15515 (3243491)	3243491..3244354	-	864	WP_148673530.1	hypothetical protein	-
LA339_RS15520 (3244605)	3244605..3244760	-	156	WP_133295396.1	TA system toxin CbtA family protein	Toxin
LA339_RS15525 (3244805)	3244805..3245161	-	357	WP_012543031.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
LA339_RS15530 (3245187)	3245187..3245408	-	222	WP_012543032.1	DUF987 domain-containing protein	-
LA339_RS15535 (3245405)	3245405..3245947	-	543	WP_032456936.1	DNA repair protein RadC	-
LA339_RS15540 (3245960)	3245960..3246403	-	444	WP_032456935.1	antirestriction protein	-
LA339_RS15545 (3246434)	3246434..3247255	-	822	WP_032456934.1	DUF932 domain-containing protein	-
LA339_RS15550 (3247355)	3247355..3247585	-	231	WP_032456933.1	DUF905 domain-containing protein	-
LA339_RS15555 (3247657)	3247657..3248106	-	450	WP_032456932.1	IrmA family protein	-
LA339_RS15560 (3248103)	3248103..3248555	-	453	WP_032456931.1	hypothetical protein	-
LA339_RS15565 (3248592)	3248592..3249161	-	570	WP_032456930.1	hypothetical protein	-
LA339_RS15570 (3249161)	3249161..3249865	-	705	WP_071996731.1	WYL domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3243491..3274049	30558

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (2-51)

Antitoxin

• Antitoxin CbeA (17-117)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5824.67 Da
• Isoelectric Point: 6.0341

>T216935 WP_133295396.1 NZ_CP083631:c3244760-3244605 [Klebsiella quasipneumoniae]
MRAAKSFLSPAAIWQMLLTHLLEQHYGLTLNDTPFSDETVTQEHFTIGIHL

Nucleotide

• Length: 156 bp

>T216935 NZ_CP113534:829924-830337 [Salmonella enterica]
GTGGTCCTGTGGCAATCTGATTTACGCGTCTCATGGCGCGCTCAGTGGATCTCATTGCTCATTCATGGGCTGGTTGCCGC
GGTGATTTTATTGATGCCCTGGCCGCTGAGTTATACCCCGTTATGGATGATACTACTGTCGCTGGTCGTGTTTGACTGTG
TACGTAGCCAGCGCAGGATTAATACCTGCCAGGGAGAGATCAAGCTACTCATGGACGGGCGCTTACGCTGGCAGGGGCAG
GACTGGACGCTCTTGCGTCCGCCCTGGTTACTGAAGAGCGGGATGGTGTTGCGTTTACGCGCAGAGTCTGGACGTCATCA
GCATTTATGGCTGGCGGCGGATAGCATGGAAGAAGCGGAATGGCGTGAGTTGCGTCGGATACTGTTACAGCAGCCGATAT
CAGGCCAACACTGA

Antitoxin

Protein

• Length: 119 a.a.
• Molecular weight: 13113.91 Da
• Isoelectric Point: 6.4736

>AT216935 WP_012543031.1 NZ_CP083631:c3245161-3244805 [Klebsiella quasipneumoniae]
MNNHSESGAIPENPPCKQWGLKSTITPCFGARLVQEGDRLHFLADRAGFNGAFSDEHVLRLDQAFPLILKQLELMLTSGE
LSPRHQHCVTLYHNGLICDADTLGSCGYVYIAVYPTQR

Nucleotide

• Length: 357 bp

>AT216935 NZ_CP113534:829677-829943 [Salmonella enterica]
ATGGATATTCACAATAAAGCACGTATTCACTGGGCATGTCGTCGCGGTATGCGCGAACTTGATATTTCCATCATGCCGTT
TTTTGAACATGAGTACGATAGTTTAAGTGATGAAGAAAAGCGTATTTTTGTCCGTTTGTTGCAGAGTGATGACCCGGATT
TATTTAACTGGTTAATGAATCACGGTAAACCGGCTGACGCTGAACTGGAACAGATGGTCCGACTCATTCAGACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA