Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mqsRA (relBE)/MqsR-MqsA
Location 4051572..4052265 Replicon chromosome
Accession NZ_CP083481
Organism Escherichia coli strain elppa9

Toxin (Protein)


Gene name mqsR Uniprot ID S1EZG2
Locus tag K9U12_RS19700 Protein ID WP_000415584.1
Coordinates 4051572..4051868 (+) Length 99 a.a.

Antitoxin (Protein)


Gene name mqsA Uniprot ID S1EBV2
Locus tag K9U12_RS19705 Protein ID WP_000650107.1
Coordinates 4051870..4052265 (+) Length 132 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9U12_RS19665 (4046660) 4046660..4046974 - 315 WP_000958598.1 putative quinol monooxygenase -
K9U12_RS19670 (4047005) 4047005..4047586 - 582 WP_000065430.1 NADPH:quinone oxidoreductase MdaB -
K9U12_RS19675 (4047905) 4047905..4048237 + 333 WP_023149630.1 DUF2645 family protein -
K9U12_RS19680 (4048283) 4048283..4049632 - 1350 WP_000673402.1 quorum sensing histidine kinase QseC -
K9U12_RS19685 (4049629) 4049629..4050288 - 660 WP_001221493.1 quorum sensing response regulator transcription factor QseB -
K9U12_RS19690 (4050440) 4050440..4050832 + 393 WP_000712658.1 OB fold stress tolerance protein YgiW -
K9U12_RS19695 (4050885) 4050885..4051367 + 483 WP_000183505.1 GyrI-like domain-containing protein -
K9U12_RS19700 (4051572) 4051572..4051868 + 297 WP_000415584.1 type II toxin-antitoxin system toxin MqsR Toxin
K9U12_RS19705 (4051870) 4051870..4052265 + 396 WP_000650107.1 type II toxin-antitoxin system antitoxin MqsA Antitoxin
K9U12_RS19710 (4052398) 4052398..4054005 + 1608 WP_001295629.1 ABC transporter substrate-binding protein -
K9U12_RS19715 (4054143) 4054143..4056401 + 2259 WP_001281841.1 DNA topoisomerase IV subunit A -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(5-97)

Antitoxin

(3-47)


Sequences


Toxin        


Download         Length: 99 a.a.        Molecular weight: 11231.96 Da        Isoelectric Point: 8.9070

>T216541 WP_000415584.1 NZ_CP083481:4051572-4051868 [Escherichia coli]
MEKRTPHTRLSQVKKLVNAGQVRTTRSALLNADELGLDFDGMCNVIIGLSESDFYKSMTTYSDHTIWQDVYRPRLVTGQV
YLKITVIHDVLIVSFKEK

Download         Length: 297 bp

>T216541 NZ_CP113116:c4911672-4911094 [Mycobacterium sp. Aquia_213]
ATGAACCGGCTCGACCTTGTCGTCGGGCCCAACGGAGCCGGTAAATCAACCTTCGTCGAATTCACGCTCGCGCCGCTGCT
GCCGACAAGCGTCTTCGTCAACGCCGACGAGATCGCCAGACAGCGCTGGCCTGCCGACGCTGCTGCCCATTCCTACGAGG
CCGCGCGGATTGCGGCCGGTACCAGGGCGAGGCTGATCGAACTGCGCCGATCGTTCATCGCCGAAACGGTGTTTTCTCAC
CCGTCCAAACTCGAGCTGATCGACAGCGCGCACGCGGCGTCCTACACCGTCGTCCTGCACGTGTTGCTCATTCCCGAGAA
GCTGGCCGTGGAGCGGGTCAAGCATCGGGTCGCCGCCGGCGGGCACGATGTCCCCGAAGCCAAGATTCGTCAACGCTACC
AACGGCTTTGGCCACTGGTTGTCACCGCCGTCGCACGCTGCGACTCCGCCACCGTGTACGACAACAGTGCGCTCAAAGGC
CCGCGCATCGTCGCCCAAATGAGTTTCGGCCAGCCGGACGGGACACCCACGTGGCCGGCGTGGACACCCCGCGAGTTGAC
GTCGCGCTGGCCCGCATAA

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14703.10 Da        Isoelectric Point: 9.2136

>AT216541 WP_000650107.1 NZ_CP083481:4051870-4052265 [Escherichia coli]
MKCPVCHQGEMVSGIKDIPYTFRGRKTVLKGIHGLYCVHCEESIMNKEESDAFMAQVKAFRASVNAETVAPEFIVKVRKK
LSLTQKEASEIFGGGVNAFSRYEKGNAQPHPSTIKLLRVLDKHPELLNEIR

Download         Length: 396 bp

>AT216541 NZ_CP113116:c4912097-4911669 [Mycobacterium sp. Aquia_213]
ATGGCTGACAGCGCGGATCGAGTTACCCGGTTCGCCGCGGACCTCGTCGACAGTGCGAAGGCCGAGGGCGCGCGGCAGAG
CCGATCGGCCAAGCAGCAACTGGATCACTGGGCGCGGGTGGGGCGCGCGGTGTCGAGCCAGCACTCCGCTGCACGTCGCC
GGGTGGAGGCGGCGCTGGCCGGGGATTTGGAACTGGGCGAATTGAGTGTCGAAGAAGGTGTCGTCTTCAACGCCGAAATC
GCCGCGGCGATCCAGGAAAACCTCAACCAGGCCAACTACGGCAAGCTGCTGGCCAAGCGTGGCGTCACCACCGTTGCCCT
TAACGAGGCCGGCGAGATCGTCGAACACCGGCCCGATGGCAGTTCGACCGTGTTGACGGCGAACTCGCGACCCGCACGGC
GCAAGAAGGTGAACGCCGGGGCCCGATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
PDB 3HI2


Antitoxin

Source ID Structure
PDB 3HI2
PDB 3GA8
PDB 3O9X
PDB 2KZ8
PDB 3FMY
PDB 3GN5
AlphaFold DB A0A7U9LU65

References