Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) ldrD-rdlD/Ldr(toxin)
Location 3699842..3700064 Replicon chromosome
Accession NZ_CP083410
Organism Escherichia coli strain RP437

Toxin (Protein)


Gene name ldrD Uniprot ID S1E8T8
Locus tag LAJ62_RS18050 Protein ID WP_000141634.1
Coordinates 3699842..3699949 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 3699998..3700064 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ62_RS18025 3695095..3695823 - 729 WP_011310329.1 cellulose biosynthesis protein BcsQ -
LAJ62_RS18030 3695859..3696047 - 189 WP_001063318.1 cellulose biosynthesis protein BcsR -
LAJ62_RS18035 3696320..3697891 + 1572 WP_001204931.1 cellulose biosynthesis c-di-GMP-binding protein BcsE -
LAJ62_RS18040 3697888..3698079 + 192 WP_000988308.1 cellulose biosynthesis protein BcsF -
LAJ62_RS18045 3698076..3699755 + 1680 WP_000191622.1 cellulose biosynthesis protein BcsG -
LAJ62_RS18050 3699842..3699949 - 108 WP_000141634.1 type I toxin-antitoxin system toxic polypeptide LdrD Toxin
- 3699998..3700064 + 67 - - Antitoxin
LAJ62_RS18055 3700425..3701696 + 1272 WP_001295225.1 aromatic amino acid transport family protein -
LAJ62_RS18060 3701726..3702730 - 1005 WP_000107012.1 dipeptide ABC transporter ATP-binding subunit DppF -
LAJ62_RS18065 3702727..3703710 - 984 WP_001196486.1 dipeptide ABC transporter ATP-binding protein -
LAJ62_RS18070 3703721..3704623 - 903 WP_000084677.1 dipeptide ABC transporter permease DppC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Type I toxin-antitoxin system, toxin Ldr

(1-35)


Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 3916.72 Da        Isoelectric Point: 9.0157

>T216389 WP_000141634.1 NZ_CP083410:c3699949-3699842 [Escherichia coli]
MTFAELGMAFWHDLAAPVIAGILASMIVNWLNKRK

Download         Length: 108 bp

>T216389 NZ_CP113037:1090054-1090263 [Staphylococcus aureus]
ATGATACATCAAAATACGATTTACACAGCGGGAATTGAAACAGAAGAACAAGTAAGTCAATTGACAGAACGCATTTCAAA
TATGATAGGTGTTCATCAAGTGAATATTAATATAATAGACGGTCAAGTAACTGTATCGTATGAAACACCAGCAAATTTGA
ATAGTATTGAAAAAGAAATCTATGATGAAGGATACAAAATTGTATTTTAG

Antitoxin


Download         Length: 67 bp

>AT216389 NZ_CP083410:3699998-3700064 [Escherichia coli]
GTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5LBJ

Antitoxin

Download structure file

References