Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4745947..4746463 Replicon chromosome
Accession NZ_CP083070
Organism Klebsiella pneumoniae strain 1230_0791_KP

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag K9F20_RS23270 Protein ID WP_009486548.1
Coordinates 4745947..4746231 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F20_RS23275 Protein ID WP_002886901.1
Coordinates 4746221..4746463 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F20_RS23245 (4741364) 4741364..4741627 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
K9F20_RS23250 (4741757) 4741757..4741930 + 174 WP_032433782.1 hypothetical protein -
K9F20_RS23255 (4741933) 4741933..4742676 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F20_RS23260 (4743033) 4743033..4745171 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K9F20_RS23265 (4745479) 4745479..4745943 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F20_RS23270 (4745947) 4745947..4746231 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F20_RS23275 (4746221) 4746221..4746463 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F20_RS23280 (4746541) 4746541..4748451 - 1911 WP_009486549.1 PRD domain-containing protein -
K9F20_RS23285 (4748474) 4748474..4749628 - 1155 WP_231538249.1 lactonase family protein -
K9F20_RS23290 (4749695) 4749695..4750435 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T216121 WP_009486548.1 NZ_CP083070:c4746231-4745947 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T216121 NZ_CP112880:3385691-3385969 [Streptomyces sp. CA-278952]
ATGGGCCACGTCACACGATTCACGGCCCACGCACAGCGTGACCTTCTCAAGGTTCCCCTGCCGGAAGCCCGACGCGTCCT
CGGCCGCCTGTCAGACCTCCAAAAAGCCTTGGACACGGGAGACCTCTCGGCGTTCGACGTCAAGCCGCTCCAGGGCCACG
AGGCACGATGGCGCCTCCGACTAGGTGGCTACCGGGCCGTCTACACCGTGGAGGGCGGTCGGCTCATCGTCTGGGTACTC
GCCGTGGGCCACCAGCGCGAGATCTATCGATCCCGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT216121 WP_002886901.1 NZ_CP083070:c4746463-4746221 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT216121 NZ_CP112880:3385445-3385687 [Streptomyces sp. CA-278952]
GTGACCGAATCCATGGCAGAGGTACGCAAGCACCTCGCGGACGTCATCGACCGCGCGCGCCGTGACGAGACGCCCACGAT
CATCACCCGCCGAGGCAAGAGTGAATACCGGCGCCTGCGCGAGGCCGCCGAGCGGTACGAGGACGAGTGGCTCAACCGAC
TCGCGGACGAGGCCGAGGCCGAGGGAACCGATGGATCAGTATCCCTCGAAGAGATGGCCGCACTCCTCCGGTCGGCCAAC
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References