Detailed information of TA system TA216094

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2671606..2673194
• Replicon: chromosome
• Accession: NZ_CP083066
• Organism: Klebsiella pneumoniae strain 1613015451

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: K9F39_RS13260
• Protein ID: WP_049109073.1
• Coordinates: 2671606..2672928 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: K9F39_RS13265
• Protein ID: WP_002904790.1
• Coordinates: 2672928..2673194 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9F39_RS13245 (2666662)	2666662..2669163	+	2502	WP_094645008.1	fimbria/pilus outer membrane usher protein	-
K9F39_RS13250 (2669151)	2669151..2670155	+	1005	WP_016946380.1	fimbrial protein	-
K9F39_RS13255 (2670297)	2670297..2671589	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
K9F39_RS13260 (2671606)	2671606..2672928	-	1323	WP_049109073.1	type II toxin-antitoxin system HipA family toxin	Toxin
K9F39_RS13265 (2672928)	2672928..2673194	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
K9F39_RS13270 (2673459)	2673459..2673785	-	327	WP_002904788.1	hydroxyisourate hydrolase	-
K9F39_RS13275 (2673782)	2673782..2674282	-	501	WP_094645009.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
K9F39_RS13280 (2674260)	2674260..2675639	-	1380	WP_004184021.1	nucleobase:cation symporter-2 family protein	-
K9F39_RS13285 (2675985)	2675985..2677139	+	1155	WP_002904783.1	FAD-dependent urate hydroxylase HpxO	-
K9F39_RS13290 (2677120)	2677120..2678043	-	924	WP_002904781.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	mgtC / iroE	2459062..2708677	249615

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (5-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49115.40 Da
• Isoelectric Point: 7.5357

>T216094 WP_049109073.1 NZ_CP083066:c2672928-2671606 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPAGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T216094 NZ_CP112873:520756-521106 [Bacillus subtilis]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGGTTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT216094 WP_002904790.1 NZ_CP083066:c2673194-2672928 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT216094 NZ_CP112873:520470-520751 [Bacillus subtilis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GXD8