Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4787773..4788289 Replicon chromosome
Accession NZ_CP083063
Organism Klebsiella pneumoniae strain 1613163991

Toxin (Protein)


Gene name relE Uniprot ID A0A2A2BGN7
Locus tag K9F41_RS23375 Protein ID WP_009486548.1
Coordinates 4787773..4788057 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F41_RS23380 Protein ID WP_002886901.1
Coordinates 4788047..4788289 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F41_RS23350 (4783190) 4783190..4783453 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
K9F41_RS23355 (4783583) 4783583..4783756 + 174 WP_002886906.1 hypothetical protein -
K9F41_RS23360 (4783759) 4783759..4784502 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F41_RS23365 (4784859) 4784859..4786997 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
K9F41_RS23370 (4787305) 4787305..4787769 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F41_RS23375 (4787773) 4787773..4788057 - 285 WP_009486548.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F41_RS23380 (4788047) 4788047..4788289 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F41_RS23385 (4788367) 4788367..4790277 - 1911 WP_009486549.1 PRD domain-containing protein -
K9F41_RS23390 (4790300) 4790300..4791454 - 1155 WP_020316350.1 lactonase family protein -
K9F41_RS23395 (4791521) 4791521..4792261 - 741 WP_009486551.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.4951

>T216080 WP_009486548.1 NZ_CP083063:c4788057-4787773 [Klebsiella pneumoniae]
MTYELEFDPRARREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T216080 NZ_CP083063:c4788057-4787773 [Klebsiella pneumoniae]
ATGACCTATGAACTGGAGTTTGATCCACGAGCCAGGCGCGAATGGCAGAAGCCTGGCGAGACGGTCAAAAAACAGTTCAA
AAATAAGCTCCAGCAGATTGTGCAGAATCCGCGAATTGAGTCGACCAGGCTGAGCGATTTACCGGATTGCTACAAAATCA
AGCTTAAGGCGTCAGGTTATCGGTTGGTGTATCAAGTACGAGATAGTGTGGTGGTGGTTTACGTTATTGCCATTGGCAAA
AGAGAGAAAGCGGCCGTTTATCATCAGGCGAATAAACGGCTCTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT216080 WP_002886901.1 NZ_CP083063:c4788289-4788047 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT216080 NZ_CP083063:c4788289-4788047 [Klebsiella pneumoniae]
ATGGCCACGCTCAATGTTCGACTGGACGATAAACTCAAAAAAGAGGCTTATGCCGTGCTGGAGAAACTCGATATGACACC
AACGGAGGCGGTACGCCTGCTGTTTCAATACATTGCGGAAAATGGCCGCATGCCGGTGAAAAGTATGACCATCAGTGATG
GCGAAGCGGCGTTATTACGCACCGTTCGCGAACGGCTGGAAAACCCACGGCCAGGGGTTAAGGTGAGTCTGGATGACCTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2A2BGN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References