Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | relBE/ParE-RelB |
Location | 4882885..4883401 | Replicon | chromosome |
Accession | NZ_CP083047 | ||
Organism | Klebsiella pneumoniae strain 400195-1-18 |
Toxin (Protein)
Gene name | relE | Uniprot ID | R4YAY3 |
Locus tag | K9F24_RS23730 | Protein ID | WP_004178374.1 |
Coordinates | 4882885..4883169 (-) | Length | 95 a.a. |
Antitoxin (Protein)
Gene name | relB | Uniprot ID | R4Y888 |
Locus tag | K9F24_RS23735 | Protein ID | WP_002886901.1 |
Coordinates | 4883159..4883401 (-) | Length | 81 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
K9F24_RS23705 (4878369) | 4878369..4878632 | - | 264 | WP_228985702.1 | PTS sugar transporter subunit IIB | - |
K9F24_RS23710 (4878762) | 4878762..4878935 | + | 174 | WP_032408826.1 | hypothetical protein | - |
K9F24_RS23715 (4878938) | 4878938..4879681 | + | 744 | WP_002886905.1 | MurR/RpiR family transcriptional regulator | - |
K9F24_RS23720 (4880038) | 4880038..4882176 | + | 2139 | WP_004186701.1 | anaerobic ribonucleoside-triphosphate reductase | - |
K9F24_RS23725 (4882417) | 4882417..4882881 | + | 465 | WP_004178375.1 | anaerobic ribonucleoside-triphosphate reductase-activating protein | - |
K9F24_RS23730 (4882885) | 4882885..4883169 | - | 285 | WP_004178374.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
K9F24_RS23735 (4883159) | 4883159..4883401 | - | 243 | WP_002886901.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
K9F24_RS23740 (4883479) | 4883479..4885389 | - | 1911 | WP_004178373.1 | PRD domain-containing protein | - |
K9F24_RS23745 (4885412) | 4885412..4886566 | - | 1155 | WP_004178372.1 | lactonase family protein | - |
K9F24_RS23750 (4886633) | 4886633..4887373 | - | 741 | WP_002886899.1 | KDGP aldolase family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 95 a.a. Molecular weight: 11155.97 Da Isoelectric Point: 10.3787
>T216020 WP_004178374.1 NZ_CP083047:c4883169-4882885 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL
Download Length: 285 bp
>T216020 NZ_CP111033:c170968-170690 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTTCTGGCGGCGGTGAACCGGCCAGC
AGCGGCCCGCACGGTGCAGCAGCTGACGGTTACACCGACCACACTGCTGACCAACCCGCGTATCGGCGAGCGGCTGGAAG
AATTCGAGCCGCGTGACGTGCGGCGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATTGCAGCGGACTCCACCATC
TACCTGCTGCGCCTGTGGCACACACGCGAGGATCGCTGA
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTTCTGGCGGCGGTGAACCGGCCAGC
AGCGGCCCGCACGGTGCAGCAGCTGACGGTTACACCGACCACACTGCTGACCAACCCGCGTATCGGCGAGCGGCTGGAAG
AATTCGAGCCGCGTGACGTGCGGCGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATTGCAGCGGACTCCACCATC
TACCTGCTGCGCCTGTGGCACACACGCGAGGATCGCTGA
Antitoxin
Download Length: 81 a.a. Molecular weight: 9045.55 Da Isoelectric Point: 6.3340
>AT216020 WP_002886901.1 NZ_CP083047:c4883401-4883159 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL
Download Length: 243 bp
>AT216020 NZ_CP111033:c171240-170968 [Pseudomonas aeruginosa]
ATGGCCGCTACCGCAAAAACCCGATCCGTCACCGCTCACGTCCCTGTCGAGCTGGCTGAACGTGTCGATGAAATCGCCGA
ACGCTTGGAGCGCTCGAAGAACTGGATCGTCAAGCAAGCACTGTCCGCCTGGCTCGACCAGGAAGAGGAACGCAGTCGCC
TGACCCGCGAGGCCCTGGCCGATGTGGATGCCGGGCGCGTGATCGACCATCAGGCCGTGCAGGCCTGGGCCGACAGCTTG
AGCACCGACACGCCGCTGCCGGTGCCGCACTGA
ATGGCCGCTACCGCAAAAACCCGATCCGTCACCGCTCACGTCCCTGTCGAGCTGGCTGAACGTGTCGATGAAATCGCCGA
ACGCTTGGAGCGCTCGAAGAACTGGATCGTCAAGCAAGCACTGTCCGCCTGGCTCGACCAGGAAGAGGAACGCAGTCGCC
TGACCCGCGAGGCCCTGGCCGATGTGGATGCCGGGCGCGTGATCGACCATCAGGCCGTGCAGGCCTGGGCCGACAGCTTG
AGCACCGACACGCCGCTGCCGGTGCCGCACTGA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A6THG1 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H3GLP0 |