Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4882885..4883401 Replicon chromosome
Accession NZ_CP083047
Organism Klebsiella pneumoniae strain 400195-1-18

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag K9F24_RS23730 Protein ID WP_004178374.1
Coordinates 4882885..4883169 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F24_RS23735 Protein ID WP_002886901.1
Coordinates 4883159..4883401 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F24_RS23705 (4878369) 4878369..4878632 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
K9F24_RS23710 (4878762) 4878762..4878935 + 174 WP_032408826.1 hypothetical protein -
K9F24_RS23715 (4878938) 4878938..4879681 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F24_RS23720 (4880038) 4880038..4882176 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K9F24_RS23725 (4882417) 4882417..4882881 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F24_RS23730 (4882885) 4882885..4883169 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F24_RS23735 (4883159) 4883159..4883401 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F24_RS23740 (4883479) 4883479..4885389 - 1911 WP_004178373.1 PRD domain-containing protein -
K9F24_RS23745 (4885412) 4885412..4886566 - 1155 WP_004178372.1 lactonase family protein -
K9F24_RS23750 (4886633) 4886633..4887373 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T216020 WP_004178374.1 NZ_CP083047:c4883169-4882885 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T216020 NZ_CP111033:c170968-170690 [Pseudomonas aeruginosa]
ATGGAGTTGAAGTGGACGAGCAAGGCCCTATCCGATCTGGCCCGCCTCTATGAGTTTCTGGCGGCGGTGAACCGGCCAGC
AGCGGCCCGCACGGTGCAGCAGCTGACGGTTACACCGACCACACTGCTGACCAACCCGCGTATCGGCGAGCGGCTGGAAG
AATTCGAGCCGCGTGACGTGCGGCGGATTCTGGTCGGGCACTACGAGATGCGCTACGAAATTGCAGCGGACTCCACCATC
TACCTGCTGCGCCTGTGGCACACACGCGAGGATCGCTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT216020 WP_002886901.1 NZ_CP083047:c4883401-4883159 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT216020 NZ_CP111033:c171240-170968 [Pseudomonas aeruginosa]
ATGGCCGCTACCGCAAAAACCCGATCCGTCACCGCTCACGTCCCTGTCGAGCTGGCTGAACGTGTCGATGAAATCGCCGA
ACGCTTGGAGCGCTCGAAGAACTGGATCGTCAAGCAAGCACTGTCCGCCTGGCTCGACCAGGAAGAGGAACGCAGTCGCC
TGACCCGCGAGGCCCTGGCCGATGTGGATGCCGGGCGCGTGATCGACCATCAGGCCGTGCAGGCCTGGGCCGACAGCTTG
AGCACCGACACGCCGCTGCCGGTGCCGCACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References