Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4882769..4883285 Replicon chromosome
Accession NZ_CP083043
Organism Klebsiella pneumoniae strain 400195-2-18

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag K9F25_RS23730 Protein ID WP_004178374.1
Coordinates 4882769..4883053 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F25_RS23735 Protein ID WP_002886901.1
Coordinates 4883043..4883285 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F25_RS23705 (4878253) 4878253..4878516 - 264 WP_228985702.1 PTS sugar transporter subunit IIB -
K9F25_RS23710 (4878646) 4878646..4878819 + 174 WP_032408826.1 hypothetical protein -
K9F25_RS23715 (4878822) 4878822..4879565 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
K9F25_RS23720 (4879922) 4879922..4882060 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K9F25_RS23725 (4882301) 4882301..4882765 + 465 WP_004178375.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F25_RS23730 (4882769) 4882769..4883053 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F25_RS23735 (4883043) 4883043..4883285 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F25_RS23740 (4883363) 4883363..4885273 - 1911 WP_004178373.1 PRD domain-containing protein -
K9F25_RS23745 (4885296) 4885296..4886450 - 1155 WP_004178372.1 lactonase family protein -
K9F25_RS23750 (4886517) 4886517..4887257 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T215999 WP_004178374.1 NZ_CP083043:c4883053-4882769 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T215999 NZ_CP111029:c3995249-3994965 [Salmonella sp. 2018103]
ATGACTTATGAACTGGAATTCGACCCGAGGGCCTTAAAAGAGTGGCATAAGCTGGGCGATACGGTGAAGGCTCAGCTTAA
GAAAAAGTTGGCTGATGTGCTATTGAACCCCAGAATCGACTCTGCCCGTTTAAACGGTCTTCCTGACTGCTATAAAATTA
AGCTTAAATCGTCCGGTTATCGTCTGGTGTACCAGGTTCGGGATGACGTTGTGATTGTGTTTGTTGTCGCGGTCGGCAAG
CGAGAACATTCAGCCGTCTATCACGATGCAAACAAACGGCTTTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT215999 WP_002886901.1 NZ_CP083043:c4883285-4883043 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT215999 NZ_CP111029:c3995481-3995239 [Salmonella sp. 2018103]
ATGGCCACGCTGAACGTCCGTCTGGATGACAAACTCAAAAATGAGGCTTATGCCGTGCTGGAAAAACTGAACATTACTCC
AACGGAAGCCGTGCGATTACTGTTCCAGTACGTCGCGGAAACGGGGCGCATGCCAGTGAAAACTGTCACTCTTAGCGACA
ATGAAGATGCACTGATTCAGACAGTTCGGGAGAGGCTGTCTAGTCCGCAAAAGGGAATCAAGGTTAGTCTGGATGACTTA
TGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References