Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4661818..4662334 Replicon chromosome
Accession NZ_CP083032
Organism Klebsiella pneumoniae strain 5208.51

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag K9F36_RS22915 Protein ID WP_002886902.1
Coordinates 4661818..4662102 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag K9F36_RS22920 Protein ID WP_002886901.1
Coordinates 4662092..4662334 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F36_RS22890 (4657234) 4657234..4657497 - 264 WP_014908078.1 PTS sugar transporter subunit IIB -
K9F36_RS22895 (4657627) 4657627..4657800 + 174 WP_032410138.1 hypothetical protein -
K9F36_RS22900 (4657803) 4657803..4658546 + 744 WP_021441079.1 MurR/RpiR family transcriptional regulator -
K9F36_RS22905 (4658903) 4658903..4661041 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
K9F36_RS22910 (4661350) 4661350..4661814 + 465 WP_023302390.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
K9F36_RS22915 (4661818) 4661818..4662102 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F36_RS22920 (4662092) 4662092..4662334 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
K9F36_RS22925 (4662412) 4662412..4664322 - 1911 WP_009486549.1 PRD domain-containing protein -
K9F36_RS22930 (4664345) 4664345..4665499 - 1155 WP_023302389.1 lactonase family protein -
K9F36_RS22935 (4665566) 4665566..4666306 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T215960 WP_002886902.1 NZ_CP083032:c4662102-4661818 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T215960 NZ_CP111005:c52941-52498 [Escherichia coli]
ATGAAGAAAACCTGGATGCTCGACACTAACATCTGCTCGTTCATCATGCGCGAGCAGCCGGCAGCGGTGCTGAAGCGCCT
GGAACAGGCGGTGCTGCGCGGTGATCGCATCGTGGTCTCGGCCGTGACGTATGCCGAGATGCGCTTCGGCGCCACCGGCC
CGAAGGCCTCGCCGCGCCATATTCAGCTGGTCGACGCGTTCTGCGCGCGCCTCGATGCCATCCTGCCCTGGGACCGGGCC
GCGGTGGACGCCACGACGGACATCCGGGTGGCGCTGCGCCTCGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
TGGGCACGCTATCGCGGCCGGCGCCGTCCTAGTGACGAACAATGTGAGAGAGTTTGAGCGGGTGCCGGGTCTGGTGCTGG
AAGACTGGGTGAAGAAAGCCGCTCTCTGCAGGGTAATTTCTTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT215960 WP_002886901.1 NZ_CP083032:c4662334-4662092 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT215960 NZ_CP111005:c53168-52938 [Escherichia coli]
ATGCGCACAGTTTCGATATTTAAAAACGGCAATAACCGCGCCATCCGTCTGCCCCGGGACCTGGATTTTGACGGCGTCAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATCATTCTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGCTGG
ACAGGGCCGCTCCGGACTTTATGGCGGAGCGTGAGGATGTGGTCAGCGATGAAGGACGCTTTGAGCCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References