Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4180098..4180717 Replicon chromosome
Accession NZ_CP083000
Organism Klebsiella pneumoniae strain 6712.08

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag K9F30_RS20630 Protein ID WP_002892050.1
Coordinates 4180499..4180717 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag K9F30_RS20625 Protein ID WP_002892066.1
Coordinates 4180098..4180472 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F30_RS20615 (4175250) 4175250..4176443 + 1194 WP_004177236.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
K9F30_RS20620 (4176466) 4176466..4179612 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
K9F30_RS20625 (4180098) 4180098..4180472 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
K9F30_RS20630 (4180499) 4180499..4180717 + 219 WP_002892050.1 HHA domain-containing protein Toxin
K9F30_RS20635 (4180876) 4180876..4181442 + 567 WP_002892030.1 maltose O-acetyltransferase -
K9F30_RS20640 (4181414) 4181414..4181554 - 141 WP_004147370.1 hypothetical protein -
K9F30_RS20645 (4181575) 4181575..4182045 + 471 WP_002892026.1 YlaC family protein -
K9F30_RS20650 (4182020) 4182020..4183471 - 1452 WP_032419337.1 PLP-dependent aminotransferase family protein -
K9F30_RS20655 (4183572) 4183572..4184270 + 699 WP_002892021.1 GNAT family protein -
K9F30_RS20660 (4184267) 4184267..4184407 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
K9F30_RS20665 (4184407) 4184407..4184670 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T215848 WP_002892050.1 NZ_CP083000:4180499-4180717 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T215848 NZ_CP110978:2644300-2644407 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT215848 WP_002892066.1 NZ_CP083000:4180098-4180472 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT215848 NZ_CP110978:c2644253-2644187 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References