Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) higBA (relBE)/COG4683-HTH_37
Location 362599..363245 Replicon chromosome
Accession NZ_CP082975
Organism Klebsiella pneumoniae strain BD-14

Toxin (Protein)


Gene name higB Uniprot ID A0A486UPU4
Locus tag K9F22_RS01685 Protein ID WP_032417639.1
Coordinates 362599..362946 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID W8UB68
Locus tag K9F22_RS01690 Protein ID WP_002920557.1
Coordinates 362946..363245 (+) Length 100 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K9F22_RS01675 (358525) 358525..359958 + 1434 WP_002920564.1 glycogen synthase GlgA -
K9F22_RS01680 (359976) 359976..362423 + 2448 WP_002920561.1 glycogen phosphorylase -
K9F22_RS01685 (362599) 362599..362946 + 348 WP_032417639.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
K9F22_RS01690 (362946) 362946..363245 + 300 WP_002920557.1 helix-turn-helix transcriptional regulator Antitoxin
K9F22_RS01695 (363308) 363308..364816 - 1509 WP_002920554.1 glycerol-3-phosphate dehydrogenase -
K9F22_RS01700 (365021) 365021..365350 + 330 WP_002920552.1 thiosulfate sulfurtransferase GlpE -
K9F22_RS01705 (365401) 365401..366231 + 831 WP_004151408.1 rhomboid family intramembrane serine protease GlpG -
K9F22_RS01710 (366281) 366281..367039 + 759 WP_002920548.1 DeoR/GlpR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(13-107)

Antitoxin

HigA2-like, helix-turn-helix domain

(9-87)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13527.52 Da        Isoelectric Point: 5.6802

>T215737 WP_032417639.1 NZ_CP082975:362599-362946 [Klebsiella pneumoniae]
MWDVETTDTFDTWFELQSRALKEDMLATILILSEFAPQLGRPYVDTVKDSTFQNMKELRVQHHGLPIRAFFAFEPLRKAI
VLCAGDKDGMNEKRFYKELITLADREFSQHLTKER

Download         Length: 348 bp

>T215737 NZ_CP110934:2629710-2629940 [Salmonella enterica]
ATGAAGGTGTATGGCAGCAATCTCGGAGAACCTCACACCAGCGCCTTTGGTGATGGGCTTTTTGAGCTTCGGATTAAAGG
TAGCGATGGCATCGCTCGCGTTTTTTACTGCACCCTGGCAGGGAAGCGCATCGTCATGCTGCACAGCTTTATAAAGAAGA
CGCAGAAAACCCCTGTAGCTGAACGCAAAAAGGCAGAAACCAGAATGAAGGAGGTTAAGCATGACTGGTAA

Antitoxin


Download         Length: 100 a.a.        Molecular weight: 10800.58 Da        Isoelectric Point: 10.1464

>AT215737 WP_002920557.1 NZ_CP082975:362946-363245 [Klebsiella pneumoniae]
MATLKELMAKQSPDSQQRIAAKAAEIRQSVALNLLREELQMSQTEMAAAMGVKQPTIAKMEQADNDPRLSTLKRYIAALG
GELSINVTLPTGKKVSFNL

Download         Length: 300 bp

>AT215737 NZ_CP110934:2629930-2630238 [Salmonella enterica]
ATGACTGGTAAACGTAATGCGCCAACTATAACGCACGATGAAATGGCCGCTAAATGGATGGAAGACCCAGCGTTCAAAGC
TGAATATGACGCCATTGCTGATGAGTTCGCGTTGCTTGACGAAATGCTGGCCGCACGTAAAGAAGCAGGTCTCACCCAGG
CTGAAGTTGCTGAACGGATGGGAACAAAAGCCACTGCTATAACCAGAATGGAAAGCAACCTTGCTGCTGGCGTCAGCGGA
CCATCTTTTACTACGCTGAAAAAGTTCGCACAGGCAACCGGGAAAAAACTCCAGATCCGCTTCGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486UPU4

Antitoxin

Source ID Structure
AlphaFold DB A0A0E1CBF8

References