Detailed information of TA system TA215554

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): hok-sok/-
• Location: 29106..29331
• Replicon: chromosome
• Accession: NZ_CP082916
• Organism: Salmonella enterica subsp. enterica serovar Newlands strain ZC-S1 3rd

Toxin (Protein)

• Gene name: hokW
• Uniprot ID: S1ELB5
• Locus tag: K8862_RS00160
• Protein ID: WP_000813254.1
• Coordinates: 29106..29261 (-)
• Length: 52 a.a.

Antitoxin (RNA)

Gene name	sokW
Locus tag	-
Coordinates	29273..29331 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8862_RS00125	24213..24494	-	282	WP_000445513.1	phage holin family protein	-
K8862_RS00130	24484..24672	-	189	WP_001688615.1	putative holin	-
K8862_RS00135	24666..24989	-	324	Protein_26	tellurite/colicin resistance protein	-
K8862_RS00140	27160..27696	-	537	WP_000640113.1	DUF1133 family protein	-
K8862_RS00145	27693..27983	-	291	WP_000774470.1	DUF1364 domain-containing protein	-
K8862_RS00150	27983..28582	-	600	WP_000940751.1	DUF1367 family protein	-
K8862_RS00155	28645..28815	-	171	WP_000734094.1	hypothetical protein	-
K8862_RS00160	29106..29261	-	156	WP_000813254.1	type I toxin-antitoxin system toxin HokD	Toxin
-	29273..29331	+	59	-	-	Antitoxin
K8862_RS00165	29688..30620	+	933	WP_000556390.1	hypothetical protein	-
K8862_RS00170	30617..31171	+	555	WP_001033796.1	hypothetical protein	-
K8862_RS00175	31333..31662	-	330	WP_001676916.1	DUF977 family protein	-
K8862_RS23140	31706..31753	-	48	Protein_35	hypothetical protein	-
K8862_RS00185	31935..32402	+	468	WP_001227859.1	helix-turn-helix domain-containing protein	-
K8862_RS00190	32787..32942	+	156	WP_085981757.1	DUF1391 family protein	-
K8862_RS00195	33050..33571	-	522	WP_000004762.1	super-infection exclusion protein B	-
K8862_RS00200	34009..34230	+	222	WP_000560208.1	cell division protein FtsZ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	23671..35542	11871

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Hok/gef cell toxic protein (6-47)

Sequences

Toxin

Protein

• Length: 52 a.a.
• Molecular weight: 5736.89 Da
• Isoelectric Point: 6.1531

>T215554 WP_000813254.1 NZ_CP082916:c29261-29106 [Salmonella enterica subsp. enterica serovar Newlands]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFTAYEPEE

Nucleotide

• Length: 156 bp

>T215554 NZ_CP110814:2609874-2609981 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 59 bp

>AT215554 NZ_CP082916:29273-29331 [Salmonella enterica subsp. enterica serovar Newlands]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Structures

Toxin

• AlphaFold DB: A0A4P7TMW0

Antitoxin