Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 3169749..3171524 Replicon chromosome
Accession NC_007952
Organism Burkholderia xenovorans LB400

Toxin (Protein)


Gene name doc Uniprot ID Q13JH4
Locus tag BXE_RS35935 Protein ID WP_011493035.1
Coordinates 3170634..3171524 (-) Length 297 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q13JH5
Locus tag BXE_RS35930 Protein ID WP_011493034.1
Coordinates 3169749..3170633 (-) Length 295 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BXE_RS35910 3164935..3166425 - 1491 WP_040125124.1 aldehyde dehydrogenase -
BXE_RS35915 3166466..3167296 - 831 WP_011493031.1 aspartate dehydrogenase -
BXE_RS35920 3167289..3168947 - 1659 WP_011493032.1 thiamine pyrophosphate-binding protein -
BXE_RS35925 3168940..3169749 - 810 WP_011493033.1 SDR family oxidoreductase -
BXE_RS35930 3169749..3170633 - 885 WP_011493034.1 IclR family transcriptional regulator Antitoxin
BXE_RS35935 3170634..3171524 - 891 WP_011493035.1 alpha/beta fold hydrolase Toxin
BXE_RS35940 3171570..3172097 - 528 WP_011493036.1 cupin domain-containing protein -
BXE_RS35945 3172124..3172891 - 768 WP_011493037.1 SDR family oxidoreductase -
BXE_RS35950 3172884..3173975 - 1092 WP_011493038.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
BXE_RS35955 3174024..3174335 - 312 WP_011493039.1 hypothetical protein -
BXE_RS35960 3174337..3174651 - 315 WP_006047381.1 non-heme iron oxygenase ferredoxin subunit -
BXE_RS35965 3175091..3176164 + 1074 WP_011493040.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(50-279)

Antitoxin

Transcription regulator IclR, C-terminal

(148-272)


Sequences

Toxin        


Download         Length: 297 a.a.        Molecular weight: 31104.21 Da        Isoelectric Point: 7.2072

>T21549 WP_011493035.1 NC_007952:c3171524-3170634 [Paraburkholderia xenovorans LB400]
MSAVPSVTADAHATLEARVARFPTQQIWLASQRAVSYREVDGAGSGALPLVLLHGIGSGAASWVQQFEMLGATRRVLAWD
APGYGASTPVAADSPAAADYASVLKEWLDALGIERCVLLGHSLGAIIAGAFAVTHAQRVAGLLLLSPAGGYGAASAEVRN
TKRDQRLAMLNELGPQGLAEQRSTNMLSAHASDEARAWVRWNMARVIPHGYAQATHLLANADLASDLARHQGRINVAVGA
DDTITTPEACERIALAARTKLQVVPRAGHAGYIEAPAAYTAIIDTFCRASDGQRSQ

Download         Length: 891 bp

>T21549 NC_007952:c3171524-3170634 [Paraburkholderia xenovorans LB400]
ATGTCCGCTGTTCCATCCGTTACCGCAGATGCACACGCCACGCTCGAAGCGCGCGTTGCGCGTTTCCCGACGCAGCAGAT
CTGGTTGGCGTCGCAACGTGCGGTGAGCTATCGCGAAGTGGATGGCGCCGGTAGCGGTGCGCTGCCGCTCGTGCTGCTGC
ACGGTATCGGTTCGGGCGCGGCGTCGTGGGTGCAGCAGTTCGAAATGCTCGGCGCGACGCGCCGCGTGCTGGCGTGGGAT
GCGCCGGGTTATGGCGCCTCCACGCCGGTCGCGGCCGACTCGCCAGCCGCGGCTGACTACGCGAGCGTGCTGAAAGAGTG
GCTCGACGCGCTCGGCATTGAACGCTGCGTGCTGCTCGGTCATTCGCTCGGCGCGATTATCGCCGGCGCGTTTGCCGTGA
CGCATGCGCAGCGCGTGGCCGGCTTGCTGCTGTTGTCGCCGGCTGGCGGTTACGGCGCGGCATCGGCAGAGGTACGCAAC
ACGAAGCGCGATCAGCGGCTCGCGATGCTGAACGAACTCGGCCCGCAAGGTCTCGCCGAACAACGCAGCACGAATATGTT
GTCCGCTCACGCAAGCGACGAAGCTCGCGCATGGGTGCGCTGGAACATGGCGCGCGTGATCCCGCACGGTTACGCGCAGG
CCACGCATCTGCTCGCCAACGCCGATCTCGCGAGCGACCTCGCGCGCCACCAGGGCCGCATCAACGTGGCCGTGGGCGCC
GACGACACCATTACCACGCCCGAAGCCTGCGAACGCATCGCGCTGGCCGCGCGCACCAAGTTGCAGGTCGTGCCTCGGGC
GGGGCACGCCGGCTATATCGAAGCACCCGCCGCGTACACCGCGATCATCGACACGTTCTGTCGCGCGAGCGACGGACAAC
GGAGCCAATGA

Antitoxin


Download         Length: 295 a.a.        Molecular weight: 32693.22 Da        Isoelectric Point: 6.9988

>AT21549 WP_011493034.1 NC_007952:c3170633-3169749 [Paraburkholderia xenovorans LB400]
MTPDTINAERDADEDRNDTTGDTAYRVPGLERGLKILTEFSPREPVLGAPELSKRLKIPRTTVFRLLQTLESLGFLERAD
KDRNYRLGVAVLRLGFEYLSSLELTDLGLPVIEALRTETGLTSHIVIRDGRDVVFVAKAQSHTPIFSSVKVNVGTRLPAH
ATTHGQVLMGDLTLDDLKKLYPEPELERFTKQTPITVDDLYERIRDDARRGFAISESSFERGISVVSAPVRNETGRIVAV
ITTTIPRHEIDASLLDSGLIDKVRRAADDLSQRLNYRPKSGPNAGSKYMKALGL

Download         Length: 885 bp

>AT21549 NC_007952:c3170633-3169749 [Paraburkholderia xenovorans LB400]
ATGACGCCCGACACCATTAACGCCGAGCGCGACGCGGACGAAGACCGCAACGACACCACGGGCGACACCGCCTATCGGGT
GCCGGGTCTCGAACGCGGTCTGAAGATTCTCACCGAGTTCTCGCCACGCGAGCCGGTTCTCGGCGCGCCGGAATTATCGA
AGCGCCTGAAGATTCCTCGCACGACGGTGTTCCGTCTGCTGCAAACCCTCGAATCGCTCGGCTTTCTCGAACGTGCCGAC
AAGGACCGCAACTATCGCCTCGGCGTTGCCGTGCTGCGGCTCGGTTTCGAATATCTGAGCTCGCTCGAACTGACCGACCT
CGGCTTGCCGGTCATCGAAGCGCTGCGTACGGAAACCGGCCTCACCAGCCACATCGTGATCCGCGATGGACGCGACGTCG
TGTTCGTCGCCAAGGCGCAAAGCCATACGCCGATTTTCAGCTCGGTGAAGGTGAACGTGGGCACGCGTCTGCCGGCTCAT
GCCACGACGCACGGGCAGGTGCTGATGGGCGACCTGACACTTGATGACTTGAAGAAGCTCTATCCCGAGCCGGAACTCGA
ACGCTTCACGAAGCAGACGCCCATCACCGTGGACGACCTGTACGAACGGATTCGCGACGACGCGCGGCGCGGTTTCGCGA
TCAGCGAGTCGTCGTTCGAACGCGGCATTTCCGTGGTGAGCGCGCCGGTGCGCAACGAAACGGGACGCATCGTCGCCGTC
ATCACGACGACGATTCCGCGCCACGAGATCGACGCGTCGCTGCTCGACAGCGGCCTGATCGACAAGGTCCGCCGCGCCGC
CGACGATCTTTCGCAGCGGCTCAACTATCGGCCGAAGAGTGGGCCGAATGCGGGCAGCAAATACATGAAGGCATTGGGGC
TCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q13JH4

Antitoxin

Source ID Structure
AlphaFold DB Q13JH5

References