Detailed information of TA system TA021547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1331993..1332548
• Replicon: chromosome
• Accession: NC_007952
• Organism: Burkholderia xenovorans LB400

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: Q13P61
• Locus tag: BXE_RS27905
• Protein ID: WP_011491474.1
• Coordinates: 1332297..1332548 (+)
• Length: 84 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: Q13P62
• Locus tag: BXE_RS27900
• Protein ID: WP_011491473.1
• Coordinates: 1331993..1332286 (+)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BXE_RS27885	1327804..1329465	-	1662	WP_011491470.1	malonate decarboxylase subunit alpha	-
BXE_RS27890	1329475..1330248	-	774	WP_011491471.1	GntR family transcriptional regulator	-
BXE_RS27895	1330429..1331727	+	1299	WP_011491472.1	MFS transporter	-
BXE_RS27900	1331993..1332286	+	294	WP_011491473.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
BXE_RS27905	1332297..1332548	+	252	WP_011491474.1	Txe/YoeB family addiction module toxin	Toxin
BXE_RS27910	1332629..1333549	-	921	WP_011491475.1	DMT family transporter	-
BXE_RS27915	1333652..1334542	+	891	WP_011491476.1	LysR family transcriptional regulator	-
BXE_RS27920	1334527..1335585	-	1059	WP_011491477.1	ABC transporter ATP-binding protein	-
BXE_RS27925	1335614..1337218	-	1605	WP_011491478.1	iron ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (2-81)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9985.43 Da
• Isoelectric Point: 7.8124

>T21547 WP_011491474.1 NC_007952:1332297-1332548 [Paraburkholderia xenovorans LB400]
MFTDDAWDDYLYWQETDRKVVRKINTLLEECRRDPYRGTGKPEALMGSMSGLWSRRITLADRLVYLPRDGKIYVIAFRFH
YDC

Nucleotide

• Length: 252 bp

>T21547 NC_007952:1332297-1332548 [Paraburkholderia xenovorans LB400]
ATGTTCACCGACGACGCGTGGGACGATTACCTGTATTGGCAAGAGACCGACCGGAAGGTCGTGCGCAAGATCAACACGCT
GCTGGAGGAGTGCCGGCGCGATCCTTATCGCGGTACGGGGAAACCGGAGGCGTTGATGGGCAGCATGAGCGGATTGTGGT
CTCGGCGTATCACGCTGGCCGACCGTCTTGTCTACTTGCCGCGAGACGGAAAGATCTACGTGATCGCCTTTCGCTTCCAC
TACGACTGCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10686.15 Da
• Isoelectric Point: 9.0641

>AT21547 WP_011491473.1 NC_007952:1331993-1332286 [Paraburkholderia xenovorans LB400]
MNVLTYSEARAGFKQAMDDVCRDHIPMLITRQTGENVVMVSLADFNAMQETLYLLSSSKNAQRLARSIAQLNAGGATARE
LLTDEQTQKPQRGGRKG

Nucleotide

• Length: 294 bp

>AT21547 NC_007952:1331993-1332286 [Paraburkholderia xenovorans LB400]
ATGAACGTCCTTACTTATAGCGAGGCGCGTGCCGGCTTCAAGCAGGCGATGGACGACGTCTGCCGCGATCACATACCCAT
GCTGATCACGAGGCAGACGGGCGAAAACGTGGTGATGGTTTCGCTCGCGGATTTCAATGCGATGCAGGAGACCTTGTATC
TGTTGAGTTCGTCGAAGAACGCCCAGCGGCTCGCCCGATCTATCGCTCAACTGAACGCCGGCGGTGCGACTGCGCGTGAA
CTGCTGACCGATGAACAGACACAGAAGCCGCAACGAGGAGGCCGCAAAGGCTGA

Structures

Toxin

• AlphaFold DB: Q13P61

Antitoxin

• AlphaFold DB: Q13P62