Detailed information of TA system TA021546

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 4698904..4699493
• Replicon: chromosome
• Accession: NC_007951
• Organism: Burkholderia xenovorans LB400

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: I2IER1
• Locus tag: BXE_RS21195
• Protein ID: WP_007179958.1
• Coordinates: 4698904..4699086 (+)
• Length: 61 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: Q13SZ3
• Locus tag: BXE_RS21200
• Protein ID: WP_011490213.1
• Coordinates: 4699083..4699493 (+)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
BXE_RS21165	4693960..4694682	-	723	WP_011490208.1	flagellar hook assembly protein FlgD	-
BXE_RS21170	4694693..4695118	-	426	WP_007179953.1	flagellar basal body rod protein FlgC	-
BXE_RS21175	4695267..4695761	-	495	WP_011490209.1	flagellar basal body rod protein FlgB	-
BXE_RS21180	4695979..4697487	+	1509	WP_011490210.1	flagellar basal body P-ring formation protein FlgA	-
BXE_RS21185	4697701..4698054	+	354	WP_011490211.1	flagellar biosynthesis anti-sigma factor FlgM	-
BXE_RS21190	4698149..4698595	+	447	WP_011490212.1	flagellar protein FlgN	-
BXE_RS21195	4698904..4699086	+	183	WP_007179958.1	type II toxin-antitoxin system HicA family toxin	Toxin
BXE_RS21200	4699083..4699493	+	411	WP_011490213.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
BXE_RS21205	4699562..4700296	-	735	WP_007179960.1	RNA polymerase sigma factor FliA	-
BXE_RS21210	4700325..4701194	-	870	WP_038457172.1	MinD/ParA family protein	-
BXE_RS21215	4701187..4703160	-	1974	WP_011490215.1	flagellar biosynthesis protein FlhF	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (6-129)

Sequences

Toxin

Protein

• Length: 61 a.a.
• Molecular weight: 6571.77 Da
• Isoelectric Point: 12.1412

>T21546 WP_007179958.1 NC_007951:4698904-4699086 [Paraburkholderia xenovorans LB400]
MKSAEVMKLIQAAGWRLIRISGSHHHFRHAARAGLVTIPHPNKDLPPGTLNSILKQAGLK

Nucleotide

• Length: 183 bp

>T21546 NC_007951:4698904-4699086 [Paraburkholderia xenovorans LB400]
ATGAAAAGCGCCGAGGTTATGAAACTCATTCAAGCGGCTGGCTGGCGGCTGATCCGCATATCGGGAAGCCACCATCATTT
CCGTCACGCGGCAAGAGCCGGTCTCGTGACCATCCCGCATCCGAACAAAGACCTTCCTCCCGGCACGTTGAACAGCATCT
TGAAACAGGCGGGACTGAAATGA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14708.72 Da
• Isoelectric Point: 4.5106

>AT21546 WP_011490213.1 NC_007951:4699083-4699493 [Paraburkholderia xenovorans LB400]
MKNLTFPIAIEPGNADHAFGVIVPDIPGCYAAGDTLEEAYANAKEAIEAHLDLLLDEGLPVPARLSLEEHRRNPDYADFT
WGLVATRNIPALKKAVRINISLPEALVQEIDTYAQARGMSRSAFLALAAEHEMAGA

Nucleotide

• Length: 411 bp

>AT21546 NC_007951:4699083-4699493 [Paraburkholderia xenovorans LB400]
ATGAAAAACCTGACTTTTCCGATCGCGATTGAACCGGGCAATGCGGATCACGCGTTCGGCGTGATCGTGCCCGACATCCC
GGGTTGTTACGCAGCAGGCGATACGCTGGAAGAGGCCTACGCAAACGCGAAAGAAGCCATTGAAGCGCATCTTGATCTGC
TGCTCGACGAAGGCTTGCCGGTCCCTGCGCGACTCTCGCTGGAGGAGCATCGGCGCAATCCCGACTATGCGGATTTCACG
TGGGGGCTTGTCGCCACCCGGAATATTCCCGCCTTGAAGAAGGCGGTGCGTATCAATATCTCGTTGCCCGAAGCGTTGGT
TCAGGAAATCGACACTTACGCCCAGGCGCGCGGCATGTCGCGCTCGGCGTTTCTGGCGCTGGCCGCGGAACATGAAATGG
CCGGTGCATGA

Structures

Toxin

• AlphaFold DB: I2IER1

Antitoxin

• AlphaFold DB: Q13SZ3