Detailed information of TA system TA215199

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yefM-yoeB (relBE)/YoeB-RelB
• Location: 1592650..1593162
• Replicon: chromosome
• Accession: NZ_CP082820
• Organism: Streptococcus pneumoniae strain SCAID PHRX1-2021

Toxin (Protein)

• Gene name: yoeB
• Uniprot ID: A0A6I3U3U7
• Locus tag: K8B76_RS07785
• Protein ID: WP_000924720.1
• Coordinates: 1592650..1592904 (-)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: K0ZY22
• Locus tag: K8B76_RS07790
• Protein ID: WP_000388572.1
• Coordinates: 1592908..1593162 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B76_RS07770 (K8B76_07770)	1589751..1590065	-	315	WP_000979235.1	DNA-directed RNA polymerase subunit omega	-
K8B76_RS07775 (K8B76_07775)	1590090..1590716	-	627	WP_000775044.1	guanylate kinase	-
K8B76_RS07780 (K8B76_07780)	1590846..1592459	-	1614	WP_000404940.1	ribonuclease Y	-
K8B76_RS07785 (K8B76_07785)	1592650..1592904	-	255	WP_000924720.1	Txe/YoeB family addiction module toxin	Toxin
K8B76_RS07790 (K8B76_07790)	1592908..1593162	-	255	WP_000388572.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K8B76_RS07795 (K8B76_07795)	1593400..1594497	-	1098	WP_000156361.1	nucleotidyltransferase	-
K8B76_RS07800 (K8B76_07800)	1594507..1595253	-	747	WP_000605157.1	class I SAM-dependent methyltransferase	-
K8B76_RS07805 (K8B76_07805)	1595356..1595709	-	354	WP_001003001.1	ribosome silencing factor	-
K8B76_RS07810 (K8B76_07810)	1595722..1596222	-	501	WP_000844707.1	cysteine hydrolase family protein	-
K8B76_RS07815 (K8B76_07815)	1596223..1596816	-	594	WP_000121653.1	bis(5'-nucleosyl)-tetraphosphatase (symmetrical) YqeK	-
K8B76_RS07820 (K8B76_07820)	1596816..1597445	-	630	WP_000151307.1	nicotinate-nucleotide adenylyltransferase	-
K8B76_RS07825 (K8B76_07825)	1597497..1597808	-	312	WP_000060169.1	ribosome assembly RNA-binding protein YhbY	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10032.48 Da
• Isoelectric Point: 7.8087

>T215199 WP_000924720.1 NZ_CP082820:c1592904-1592650 [Streptococcus pneumoniae]
MLLKFTEDAWADYCYWQNQDKKTLKRINKLIKDIQRDPFTGIGKPEPLKYDYQGACSRRIDAENRLIYMMDGDSVAFLSF
KDHY

Nucleotide

• Length: 255 bp

>T215199 NZ_CP110532:c3834432-3834022 [Enterobacter roggenkampii]
GTGGTCCTGTGGCAATCTGATCTTCGCGTCTCGTGGCGCTCGCAGTGGATGTCTTTATTGCTCCACGGCCTGGTTGCGGC
CATTGTGTTACTGATGCCGTGGCCGCTGAGCTATACGCCGCTGTGGCTGCTGCTACTTTCGTTTGTCGTTTTTGACAGCG
TACGCAGCCAGCGTCGCATTAATGCCCGTCAGGGAGAGATCAAGTTACTGATGGATTCCCGCCTGCGCTGGCAGGGAAAA
GAGTGGGATATTCTCGGTATGCCCTGGATGCTCAACTGCGGCATGATGTTACGGCTACGCAAGGTGGACGGCGGGCGTTG
CCAGCATCTGTGGCTGGCGGCTGACAGTATGGATGCTGCTGAGTGGCGAGACCTGCGCCGGATGCTATTGCAACAGACGA
CGCAGGGGTAA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9706.00 Da
• Isoelectric Point: 4.8430

>AT215199 WP_000388572.1 NZ_CP082820:c1593162-1592908 [Streptococcus pneumoniae]
MEAVLYSTFRNHLKDYMKKVNDEFEPLTVVNKNPDEDIVVLSKSEWDSIQETLRIAQNKELSDKVLRGMAQVRAGSTQVH
VIEE

Nucleotide

• Length: 255 bp

>AT215199 NZ_CP110532:c3834679-3834413 [Enterobacter roggenkampii]
ATGGATATTAACAACAAGGCCCGTATTCACTGGGCGTGCCGTCGCGGCATGCGTGAACTTGATATTTCCATCATGCCTTT
CTTCGAATATGAGTATGACACCTTAAGCGACGACGATAAGCGTCTGTTTGTCCGCCTGCTTGAGTCTGACGATCCGGATT
TATTCAACTGGCTGATGAACCACGGCAAACCCGCCGACACCGAGTTGCAACGGATGGTGCAATTAATTCAAACACGGAAT
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A6I3U3U7

Antitoxin

• AlphaFold DB: K0ZY22