Detailed information of TA system TA215197

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 985587..986085
• Replicon: chromosome
• Accession: NZ_CP082820
• Organism: Streptococcus pneumoniae strain SCAID PHRX1-2021

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K8B76_RS04865
• Protein ID: WP_001812387.1
• Coordinates: 985831..986085 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B1IC20
• Locus tag: K8B76_RS04860
• Protein ID: WP_000208080.1
• Coordinates: 985587..985829 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8B76_RS04840 (K8B76_04840)	981409..982584	+	1176	WP_000886147.1	A/G-specific adenine glycosylase	-
K8B76_RS04845 (K8B76_04845)	982639..983343	+	705	WP_000722076.1	response regulator YycF	-
K8B76_RS04850 (K8B76_04850)	983336..984685	+	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	-
K8B76_RS04855 (K8B76_04855)	984687..985496	+	810	WP_001289493.1	MBL fold metallo-hydrolase	-
K8B76_RS04860 (K8B76_04860)	985587..985829	+	243	WP_000208080.1	DUF6290 family protein	Antitoxin
K8B76_RS04865 (K8B76_04865)	985831..986085	+	255	WP_001812387.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K8B76_RS04870 (K8B76_04870)	986132..986906	+	775	Protein_968	ion channel	-
K8B76_RS04875 (K8B76_04875)	987169..988155	-	987	WP_000204727.1	L-lactate dehydrogenase	-
K8B76_RS04880 (K8B76_04880)	988349..990817	+	2469	WP_001152989.1	DNA gyrase subunit A	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (7-84)

Antitoxin

• Protein of unknown function DUF6290 (1-73)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10110.85 Da
• Isoelectric Point: 10.7632

>T215197 WP_001812387.1 NZ_CP082820:985831-986085 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQINVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Nucleotide

• Length: 255 bp

>T215197 NZ_CP110532:1700081-1700602 [Enterobacter roggenkampii]
GTGGACAATCTCACGATCGAAATGTTTTCAGAGGGAAAAGACTATAATTTCAGGGACTTCGATTGTGGTGAACCCTCGCT
AAATGTCTTCCTCACAGAACATCTGGTGCGTCAGCACAATGGGCGTATTTTACGAGGCTATTTGCTTAAAGATCGCGATG
GTCCGCGAGTCCTGGGCTATTACACGTTGTCTGGTAGTTGCTTTGAAAAAGCGATGCTGCCTTCTAAGACTCAGCAGCGT
CGGATCCCTTATAGCAACGTACCGAGTGTAACGCTGGGACGTCTGGCGATACATAAAGACTTACAGGGGCTGGAGTGGGG
AACGACGCTCGTCACGCATGCCATGCGGGTTGTCTATCTGGCATCGCAGGCGGTGGGTGTACACGGAATATTTGTTGATG
CACTCAACGACCAGGCAAAACAATTTTATCTGAAGCAGGGCTTTATTCCGCTGACGGATGAAAACAGCCATTCTCTTTTC
TTTCCTACAAAATCTATCGAACGACTGTTTGAGCAGGCGTGA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9205.46 Da
• Isoelectric Point: 4.0527

>AT215197 WP_000208080.1 NZ_CP082820:985587-985829 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Nucleotide

• Length: 243 bp

>AT215197 NZ_CP110532:1699805-1700074 [Enterobacter roggenkampii]
ATGCCAGCATTGAAAAAACAGCGTATCGATCTTCGCTTAACGGACGAAGACAAAACAATGATTGAAGAAGCGGCAGCGAT
GACGAATCAAACGATCACCCAGTTTATGGTGAACAGTGCGTCAGAGCGGGCAGCGGAAGTCATCGAGCAGCACCGCCGTC
TCGTATTAAACGAAGCATCCTGGAATGCGGTGATGGATGCCATCGACAATCCACCAGAGCCAAATGAACGCCTGAAGCGA
GCGGCGAAACGTCTTCGAAACATGGAGTGA

Structures

Antitoxin

• AlphaFold DB: A0A064C2J7