Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yefM-yoeB (relBE)/Txe-RelB
Location 2556053..2556570 Replicon chromosome
Accession NZ_CP082815
Organism Staphylococcus aureus strain SCAID WND1-2021 (598)

Toxin (Protein)


Gene name yoeB Uniprot ID A0A170NWK0
Locus tag K8B78_RS12785 Protein ID WP_000251928.1
Coordinates 2556053..2556319 (-) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A166LMC5
Locus tag K8B78_RS12790 Protein ID WP_000584497.1
Coordinates 2556319..2556570 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B78_RS12760 (2551262) 2551262..2551798 - 537 WP_000024292.1 GNAT family N-acetyltransferase -
K8B78_RS12765 (2552266) 2552266..2553090 - 825 WP_000594640.1 formate/nitrite transporter family protein -
K8B78_RS12770 (2553293) 2553293..2553475 - 183 WP_000079140.1 hypothetical protein -
K8B78_RS12775 (2553561) 2553561..2554027 - 467 Protein_2491 SRPBCC domain-containing protein -
K8B78_RS12780 (2554213) 2554213..2555760 - 1548 WP_000727771.1 zinc ABC transporter substrate-binding lipoprotein AdcA -
K8B78_RS12785 (2556053) 2556053..2556319 - 267 WP_000251928.1 Txe/YoeB family addiction module toxin Toxin
K8B78_RS12790 (2556319) 2556319..2556570 - 252 WP_000584497.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
K8B78_RS12795 (2556734) 2556734..2556834 - 101 Protein_2495 hypothetical protein -
K8B78_RS12800 (2556841) 2556841..2557440 - 600 WP_000162804.1 DsbA family protein -
K8B78_RS12805 (2557459) 2557459..2557821 - 363 WP_000819843.1 DUF4467 domain-containing protein -
K8B78_RS12810 (2558076) 2558076..2559326 + 1251 WP_001012237.1 FemA/FemB family glycyltransferase FmhA -
K8B78_RS12815 (2559423) 2559423..2560154 - 732 WP_000615467.1 amino acid ABC transporter ATP-binding protein -
K8B78_RS12820 (2560151) 2560151..2560870 - 720 WP_000479573.1 amino acid ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(8-88)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10465.06 Da        Isoelectric Point: 10.1628

>T215194 WP_000251928.1 NZ_CP082815:c2556319-2556053 [Staphylococcus aureus]
MVRLNITFSPQAFEDYKYFQQNDKKMVKKINELIKSIDRNGALKGIGKPEKLKSNLTGYYSRRINHEHRLVYTVDDNHIK
IASCKYHY

Download         Length: 267 bp

>T215194 NZ_CP110532:c251487-251200 [Enterobacter roggenkampii]
ATGCATAAATTAACACCTTACGATCCCGCCAACGCGTTGGTGGATGACGAGGAAATCGCCGTGTTTATCGCTGATGCACT
AGAAACAGGCGACTCGACATATATCGCTAAAGCCCTTGGTGTTGTCGCGCGAGCCAAAGGCATGTCGAACATTTCACAGC
AAACCGGTTTATCACGTGAGCAGCTTTATCGGTCATTCAGTGATAAAGGAAACCCAACGCTCAATACCACGCTCGCGGTC
ATGAAAGCATTGGGTTTTGGGCTAACACTCAAACACGCCGGGGATTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9401.54 Da        Isoelectric Point: 4.3407

>AT215194 WP_000584497.1 NZ_CP082815:c2556570-2556319 [Staphylococcus aureus]
MIIKNYSYARQNLKALMTKVNDDSDIVTVTSTDDKNVVIMSESDYNSMMETLYLQQNPNNAEHLAQSIADLERGKTVTKD
IDV

Download         Length: 252 bp

>AT215194 NZ_CP110532:c251796-251494 [Enterobacter roggenkampii]
ATGAAGGAGATTGTTCAGACAGAATCCTTCCGACGCTGGGAGCAAAACTTAAAAGATCGACGAGCGAAGACCATTATCGC
TTCCCGCCTCTTTCGGTTGGCAAATGGCTTAGCGGGCGACGTTAAACCCGTGGGAGAAGGTATAAGTGAGCTAAGGATCT
ACTTTGGTCCGGGCTACAGGATCTATTTTAAAGACCAGGGCAATTACATCATCGTGCTGTTATGTGGTGGTGACAAAAGC
AGCCAGGCCAGAGACATACTGATGGCAAAAATGCTGAGCAATGTATCCCAATGGCAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A170NWK0

Antitoxin

Source ID Structure
AlphaFold DB A0A166LMC5

References