Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) SprA2-SprA2AS/-
Location 2571228..2571412 Replicon chromosome
Accession NZ_CP082789
Organism Staphylococcus aureus strain HL24830

Toxin (Protein)


Gene name SprA2 Uniprot ID Q2FVI9
Locus tag K3B00_RS13015 Protein ID WP_000482650.1
Coordinates 2571305..2571412 (-) Length 36 a.a.

Antitoxin (RNA)


Gene name SprA2AS
Locus tag -
Coordinates 2571228..2571288 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K3B00_RS13000 2566738..2566905 - 168 WP_001792506.1 hypothetical protein -
K3B00_RS13005 2567136..2568869 - 1734 WP_000486494.1 ABC transporter ATP-binding protein -
K3B00_RS13010 2568894..2570657 - 1764 WP_001064820.1 ABC transporter ATP-binding protein -
- 2571228..2571288 + 61 - - Antitoxin
K3B00_RS13015 2571305..2571412 - 108 WP_000482650.1 type I toxin-antitoxin system Fst family toxin Toxin
K3B00_RS13020 2571546..2571932 - 387 WP_000779358.1 flippase GtxA -
K3B00_RS13025 2572190..2573332 + 1143 WP_001176863.1 glycerate kinase -
K3B00_RS13030 2573392..2574051 + 660 WP_000831298.1 membrane protein -
K3B00_RS13035 2574233..2575444 + 1212 WP_223065219.1 multidrug effflux MFS transporter -
K3B00_RS13040 2575567..2576040 - 474 WP_000456489.1 GyrI-like domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 36 a.a.        Molecular weight: 4011.78 Da        Isoelectric Point: 11.0582

>T215072 WP_000482650.1 NZ_CP082789:c2571412-2571305 [Staphylococcus aureus]
MFNLLINIMTSAISGCLVAFFAHWLRTRNNKKGDK

Download         Length: 108 bp

>T215072 NZ_CP110398:716575-716748 [Shigella sonnei]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 61 bp

>AT215072 NZ_CP082789:2571228-2571288 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2C9TTS8

Antitoxin

Download structure file

References