Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 4587151..4587776 Replicon chromosome
Accession NC_007907
Organism Desulfitobacterium hafniense Y51

Toxin (Protein)


Gene name pemK Uniprot ID Q24Q87
Locus tag DSY_RS21340 Protein ID WP_005817423.1
Coordinates 4587151..4587501 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID Q24Q86
Locus tag DSY_RS21345 Protein ID WP_011461523.1
Coordinates 4587498..4587776 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DSY_RS21320 4582979..4583179 - 201 WP_011461520.1 YezD family protein -
DSY_RS21325 4583237..4583545 - 309 WP_041272609.1 DUF2325 domain-containing protein -
DSY_RS21330 4583808..4585943 - 2136 WP_005817414.1 molybdopterin-dependent oxidoreductase -
DSY_RS21335 4586232..4586954 - 723 WP_011461522.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
DSY_RS21340 4587151..4587501 - 351 WP_005817423.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DSY_RS21345 4587498..4587776 - 279 WP_011461523.1 ribbon-helix-helix protein, CopG family Antitoxin
DSY_RS21350 4588006..4588770 - 765 WP_005817427.1 glutamine amidotransferase -
DSY_RS21355 4588773..4590173 - 1401 WP_011461524.1 DUF1727 domain-containing protein -
DSY_RS21360 4590309..4591325 - 1017 WP_005817430.1 2-hydroxyacid dehydrogenase family protein -
DSY_RS21365 4591618..4592148 + 531 WP_011461525.1 gamma carbonic anhydrase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-39)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12824.86 Da        Isoelectric Point: 5.8944

>T21505 WP_005817423.1 NC_007907:c4587501-4587151 [Desulfitobacterium hafniense Y51]
MIIKRGEIYYAELNPVVGSEQGGTRPVLVIQNDIGNQFSPTTIIAAITSQIAKAKLPTHVEVRAKRSGLERDSVILTEQI
RTIDKSRLKEKVAVLDEEVMLRVDQAIEISLGLTDI

Download         Length: 351 bp

>T21505 NC_007907:c4587501-4587151 [Desulfitobacterium hafniense Y51]
ATGATTATAAAACGCGGGGAAATCTACTATGCTGAACTCAACCCCGTCGTCGGATCCGAGCAAGGCGGTACCCGCCCTGT
GTTGGTGATCCAAAATGATATCGGAAATCAGTTTAGTCCGACGACTATTATAGCTGCGATTACATCTCAGATTGCTAAAG
CAAAGCTGCCGACTCATGTGGAGGTGCGGGCCAAGCGCAGTGGTTTGGAACGGGATTCGGTCATTTTGACGGAACAGATC
CGAACGATTGACAAAAGCCGCCTCAAGGAGAAGGTCGCCGTTCTTGATGAAGAAGTGATGCTGAGGGTGGATCAAGCGAT
TGAAATCAGTTTAGGACTGACTGATATTTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10818.27 Da        Isoelectric Point: 4.6550

>AT21505 WP_011461523.1 NC_007907:c4587776-4587498 [Desulfitobacterium hafniense Y51]
VAESKRIMISLPENLLAEVDDVVTLENRNRSEFIREAINSVLHERRKRGIREQMRKGYEEMAQLNLAIARELFLAEEEVQ
VVYEDSNVECQR

Download         Length: 279 bp

>AT21505 NC_007907:c4587776-4587498 [Desulfitobacterium hafniense Y51]
GTGGCAGAGAGTAAGCGGATAATGATTAGTTTGCCGGAGAATTTGCTCGCGGAAGTGGATGATGTCGTTACGCTTGAGAA
TAGAAATCGTAGCGAATTTATACGTGAAGCAATCAACAGTGTTCTTCATGAACGCCGGAAACGGGGAATCCGCGAACAGA
TGCGTAAAGGTTATGAGGAAATGGCTCAATTGAACTTAGCCATTGCCAGAGAGCTGTTCCTTGCTGAGGAAGAGGTCCAG
GTGGTTTATGAAGATTCTAATGTGGAGTGTCAGAGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1M7T493

Antitoxin

Source ID Structure
AlphaFold DB A0A1M7T474

References