Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 2089181..2089982 Replicon chromosome
Accession NZ_CP082777
Organism Escherichia coli O25:H1 strain CU39ES-1

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2V687
Locus tag K8B91_RS09950 Protein ID WP_000854739.1
Coordinates 2089602..2089982 (+) Length 127 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0P7R0L9
Locus tag K8B91_RS09945 Protein ID WP_001285482.1
Coordinates 2089181..2089555 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B91_RS09910 (2085269) 2085269..2085724 + 456 WP_000581502.1 IrmA family protein -
K8B91_RS09915 (2085867) 2085867..2085956 + 90 WP_230607454.1 DUF905 family protein -
K8B91_RS09920 (2086135) 2086135..2086956 + 822 WP_001234710.1 DUF932 domain-containing protein -
K8B91_RS09925 (2087219) 2087219..2087692 + 474 WP_000855076.1 antirestriction protein -
K8B91_RS09930 (2087708) 2087708..2088184 + 477 WP_001186170.1 RadC family protein -
K8B91_RS09935 (2088247) 2088247..2088468 + 222 WP_000692315.1 DUF987 domain-containing protein -
K8B91_RS09940 (2088487) 2088487..2089131 + 645 WP_000086763.1 hypothetical protein -
K8B91_RS09945 (2089181) 2089181..2089555 + 375 WP_001285482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K8B91_RS09950 (2089602) 2089602..2089982 + 381 WP_000854739.1 TA system toxin CbtA family protein Toxin
K8B91_RS09955 (2089979) 2089979..2090467 + 489 WP_021571552.1 DUF5983 family protein -
K8B91_RS09960 (2090487) 2090487..2090684 + 198 WP_000772027.1 DUF957 domain-containing protein -
K8B91_RS09965 (2090769) 2090769..2091612 + 844 Protein_1931 DUF4942 domain-containing protein -
K8B91_RS09975 (2092083) 2092083..2093021 + 939 WP_000351287.1 glyoxylate/hydroxypyruvate reductase GhrA -
K8B91_RS09980 (2093076) 2093076..2093813 + 738 WP_000283664.1 zinc-binding phosphatase -
K8B91_RS09985 (2093837) 2093837..2094391 + 555 WP_001001909.1 molecular chaperone YcdY -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 127 a.a.        Molecular weight: 14214.14 Da        Isoelectric Point: 6.4773

>T215000 WP_000854739.1 NZ_CP082777:2089602-2089982 [Escherichia coli O25:H1]
MKTLPDTHVREASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGVPSQLINSIDILRARRATGLMTRDNYRTVNDITLGRHPEEAKQ

Download         Length: 381 bp

>T215000 NZ_CP110361:15076-15939 [Enterococcus faecium]
ATGGCAAATATAGTCAATTTTACTGACAAACAATTTGAGAATCGCTTAAATGATAATTTAGAAGAATTGATTCAAGGAAA
AAAAGCGGTTGAATCGCCAACCGCTTTTTTACTTGGTGGGCAACCAGGGTCAGGGAAAACCAGTTTGCGATCAGCAATTT
TTGAAGAAACACAAGGGAATGTTATTGTCATTGATAATGATACCTTTAAACAACAGCACCCTAATTTTGATGAACTAGTG
AAACTTTATGAAAAAGACGTAGTAAAACACGTTACCCCTTATTCTAATCGCATGACAGAAGCGATCATAAGCCGTTTGAG
CGATCAAGGGTATAATTTGGTGATCGAAGGTACAGGACGAACAACAGACGTTCCTATTCAAACCGCAACAATGCTTCAAG
CCAAAGGTTATGAAACAAAAATGTATGTCATGGCAGTACCTAAAATCAACTCATATTTAGGAACAATTGAACGATATGAA
ACCATGTATGCAGATGATCCAATGACAGCCAGGGCAACACCAAAACAAGCGCATGATATTGTTGTCAAAAACTTACCGAC
CAATTTAGAAACCCTTCATAAAACGGGCTTATTTAGCGATATAAGGCTATATAACAGAGAAGGAGTAAAACTCTATTCAA
GTTTGGAAACACCTTCTATTAGTCCAAAAGAAACCTTAGAAAAAGAATTGAATCGTAAAGTATCAGGGAAAGAAATTCAA
CCGACTTTAGAACGAATAGAGCAAAAAATGGTTCTAAATAAACACCAAGAGACACCTGAATTTAAAGCAATTCAACAAAA
ATTGGAAAGCTTGCAGCCACCTACACCACCAATACCCAAAACACCTAAACTTCCAGGACTTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 13791.44 Da        Isoelectric Point: 4.7511

>AT215000 WP_001285482.1 NZ_CP082777:2089181-2089555 [Escherichia coli O25:H1]
VSDTLHETNYPDDNNDRPWWGLPCTVTPCFGARLVQEGNQLHYLADRAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSCGYVYMAVYPTLAPATTS

Download         Length: 375 bp

>AT215000 NZ_CP110361:14802-15074 [Enterococcus faecium]
ATGGCAGTTACGTATGAAAAAACATTTGAAATAGAGATCATTAACGAATTATCGGCAAGCGTTTATAATCGAGTATTAAA
CTATGTTTTGAACCATGAATTAAATAAAAATGACTCTCAATTATTGGAAGTCAATTTATTAAACCAATTAAAGCTTGCAA
AACGTGTAAATCTTTTTGATTATTCTTTAGAAGAATTACAAGCCGTTCATGAGTATTGGCGGTCAATGAATCGTTACTCA
AAACAAGTTTTGAATAAAGAGAAAGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2V687

Antitoxin

Source ID Structure
AlphaFold DB A0A0P7R0L9

References