Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 607873..608707 Replicon chromosome
Accession NZ_CP082774
Organism Escherichia coli O16:H6 strain CU37RT-2

Toxin (Protein)


Gene name yeeV Uniprot ID A0A8E0IX31
Locus tag K8B88_RS02885 Protein ID WP_000854689.1
Coordinates 607873..608250 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A8E0IVP8
Locus tag K8B88_RS02890 Protein ID WP_001285599.1
Coordinates 608327..608707 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B88_RS02850 (603119) 603119..604516 + 1398 WP_234247922.1 PTS ascorbate transporter subunit IIC -
K8B88_RS02855 (604532) 604532..604837 + 306 WP_000218362.1 PTS ascorbate transporter subunit IIB -
K8B88_RS02860 (604847) 604847..605311 + 465 WP_000776505.1 PTS ascorbate transporter subunit IIA -
K8B88_RS02865 (605325) 605325..605975 + 651 WP_000056749.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
K8B88_RS02870 (606247) 606247..607094 - 848 Protein_544 DUF4942 domain-containing protein -
K8B88_RS02875 (607179) 607179..607376 - 198 WP_000839236.1 DUF957 domain-containing protein -
K8B88_RS02880 (607388) 607388..607876 - 489 WP_001530850.1 DUF5983 family protein -
K8B88_RS02885 (607873) 607873..608250 - 378 WP_000854689.1 TA system toxin CbtA family protein Toxin
K8B88_RS02890 (608327) 608327..608707 - 381 WP_001285599.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K8B88_RS02895 (608757) 608757..609401 - 645 WP_000086755.1 hypothetical protein -
K8B88_RS02900 (609420) 609420..609641 - 222 WP_000692345.1 DUF987 domain-containing protein -
K8B88_RS02905 (609710) 609710..610186 - 477 WP_001424026.1 RadC family protein -
K8B88_RS02910 (610202) 610202..610675 - 474 WP_000855059.1 antirestriction protein -
K8B88_RS02915 (611016) 611016..611522 - 507 Protein_553 DUF932 domain-containing protein -
K8B88_RS02920 (611606) 611606..612031 + 426 WP_000422741.1 transposase -
K8B88_RS02925 (612028) 612028..612378 + 351 WP_000624722.1 IS66 family insertion sequence element accessory protein TnpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14042.07 Da        Isoelectric Point: 9.1510

>T214917 WP_000854689.1 NZ_CP082774:c608250-607873 [Escherichia coli O16:H6]
MKTLPDTHVRAASRCPSPVTIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T214917 NZ_CP110344:2434441-2435016 [Pseudomonas aeruginosa]
ATGAGGCATTCCCCATTCACCGCCGTCTACGACGCGTGCGTTCTATATCCCGCGCCACTGCGGGATTTCCTGATGTGGCT
CGGCCTGTCTGGCCGCTTCCGGGCGCGGTGGAGCCAAGCCATTCATGAGGAGTGGAAACGCAACCTGTTGATCAACCGCC
CCGATCTCACCCGGGTTCAGGTCGACAGGACGTCGGATCTCATGGACCGGGCAATTCCGGACGGCTTGGTGGAGGGCTAC
GAAGCGCTCGTGGCAGGCCTGACATTGCCCGATCCGGACGACCGGCACGTCCTGGCTGCGGCGATTCGCTGCGGTGCGAG
CGTGATTGTGACGTTCAACGAACGGGATTTCCCGAACGATCTGCTGGCTCCGTACGGCATCGAATCGCAGCACCCCGATG
AGTTTGTGGACAACCTACTGGATCTGGACGCGGCCGCCGTGGTGTCGGCTGCGCAGCGCCAGCGTGCCCAACTCAAGCAT
CCGCCGATCGAGGTGGACCGCTATCTCGAAATCCTGCTGCGCCAAGGCCTTGTGCAAACGACCAAGGTGCTGGCGACCTA
TCGCACCATTCTCTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13984.78 Da        Isoelectric Point: 5.0823

>AT214917 WP_001285599.1 NZ_CP082774:c608707-608327 [Escherichia coli O16:H6]
MSDTLPGTTLPDDNKDRPWWGLPCTVTPCFGARLLQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT214917 NZ_CP110344:2433974-2434444 [Pseudomonas aeruginosa]
ATGACCACCGCCACTGCCCAATCCAAGATGACCCTTCCCGCCGCGGGAGAGGTGAAGGCAGCCGTCCAGGGTCAACGTGC
CTTGGCGGCTTACCTCGCAACCCAGTTCGAGACGCAGCACATCCAGATCTTTGATGACCACAAACAGGCTCATCAGGTGG
AACTGCCTACCTCGGCTTTACGCCTGCTGGTCGACATCCTGGCCGAGTTGGCCGATGGCAATGCAGTAAAGGTGGTGCCC
GTCCATGCAGAGCTGACGACCCAAGAGGCGGCGGACTTGCTCAACGTGTCCCGTCCCCATTTCGTCAAGCTGCTCGAAGA
TGGGGTGTTGGCATTTCATCGCACCGGCAAGCACCGCAGGGTGAGGTTCGCCGATCTGATGCAGTACAAGGAAGCGCGCG
AGCGCGCCAGTGAGCAGGCGATGGCCGAACTCGCTCAGCAGTCGCAAGAGTTGGGAATGGGATACGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References