Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 491557..492392 Replicon chromosome
Accession NZ_CP082774
Organism Escherichia coli O16:H6 strain CU37RT-2

Toxin (Protein)


Gene name yeeV Uniprot ID Q8VR61
Locus tag K8B88_RS02240 Protein ID WP_000854747.1
Coordinates 491557..491934 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3P1Z1K5
Locus tag K8B88_RS02245 Protein ID WP_021538665.1
Coordinates 492024..492392 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8B88_RS02220 (487649) 487649..489187 - 1539 WP_001187191.1 lysine decarboxylation/transport transcriptional activator CadC -
K8B88_RS02225 (489924) 489924..490778 - 855 WP_001588930.1 DUF4942 domain-containing protein -
K8B88_RS02230 (490863) 490863..491060 - 198 WP_000839291.1 DUF957 domain-containing protein -
K8B88_RS02235 (491072) 491072..491560 - 489 WP_000761667.1 DUF5983 family protein -
K8B88_RS02240 (491557) 491557..491934 - 378 WP_000854747.1 TA system toxin CbtA family protein Toxin
K8B88_RS02245 (492024) 492024..492392 - 369 WP_021538665.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
K8B88_RS02250 (492467) 492467..492688 - 222 WP_001825901.1 DUF987 domain-containing protein -
K8B88_RS02255 (492751) 492751..493227 - 477 WP_001186747.1 RadC family protein -
K8B88_RS02260 (493243) 493243..493728 - 486 WP_021538211.1 antirestriction protein -
K8B88_RS02265 (493820) 493820..494638 - 819 WP_001234693.1 DUF932 domain-containing protein -
K8B88_RS02270 (494739) 494739..494972 - 234 WP_021538212.1 DUF905 family protein -
K8B88_RS02275 (494978) 494978..495655 - 678 WP_001097364.1 hypothetical protein -
K8B88_RS02280 (495774) 495774..496658 - 885 WP_000010387.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 480160..505139 24979


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14095.03 Da        Isoelectric Point: 6.8524

>T214916 WP_000854747.1 NZ_CP082774:c491934-491557 [Escherichia coli O16:H6]
MKTLPDTHVREASSCPSPVTIWQTLLSRLLGQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPEF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNDITLGKHPEAKQ

Download         Length: 378 bp

>T214916 NZ_CP110344:1856132-1856719 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13465.18 Da        Isoelectric Point: 6.2015

>AT214916 WP_021538665.1 NZ_CP082774:c492392-492024 [Escherichia coli O16:H6]
VSDTFSGTTHPDDNRGRPWWGLPCTVTPCFGARLVQEGNQLHYLADHAGIRGQFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGCVYLAVYPTPETKK

Download         Length: 369 bp

>AT214916 NZ_CP110344:1856786-1857640 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTGGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGCTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGTGAGACGGTGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGTGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGGCAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGCGTGGC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCATCCTTGACGATCTACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VFZ1

Antitoxin

Source ID Structure
AlphaFold DB A0A3P1Z1K5

References