Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) higBA (relBE)/HigB-HigA
Location 4611967..4612721 Replicon chromosome
Accession NZ_CP082338
Organism Salmonella enterica subsp. enterica strain IBG7b4

Toxin (Protein)


Gene name higB Uniprot ID B5F003
Locus tag K7H10_RS22350 Protein ID WP_000558166.1
Coordinates 4611967..4612278 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name higA Uniprot ID -
Locus tag K7H10_RS22355 Protein ID WP_001259011.1
Coordinates 4612275..4612721 (+) Length 149 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K7H10_RS22320 (4607625) 4607625..4608527 + 903 WP_000331361.1 formate dehydrogenase subunit beta -
K7H10_RS22325 (4608524) 4608524..4609159 + 636 WP_000829025.1 formate dehydrogenase cytochrome b556 subunit -
K7H10_RS22330 (4609156) 4609156..4610085 + 930 WP_000027730.1 formate dehydrogenase accessory protein FdhE -
K7H10_RS22335 (4610132) 4610132..4610422 - 291 WP_000362050.1 DNA-binding transcriptional regulator -
K7H10_RS22340 (4610423) 4610423..4610734 - 312 WP_052934519.1 toxin HigB-2 -
K7H10_RS22345 (4610952) 4610952..4611881 + 930 WP_052934520.1 alpha/beta hydrolase -
K7H10_RS22350 (4611967) 4611967..4612278 + 312 WP_000558166.1 type II toxin-antitoxin system HigB family toxin Toxin
K7H10_RS22355 (4612275) 4612275..4612721 + 447 WP_001259011.1 type II toxin-antitoxin system HigA family antitoxin Antitoxin
K7H10_RS22360 (4612736) 4612736..4613677 - 942 WP_001518251.1 fatty acid biosynthesis protein FabY -
K7H10_RS22365 (4613722) 4613722..4614159 - 438 WP_000560969.1 D-aminoacyl-tRNA deacylase -
K7H10_RS22370 (4614156) 4614156..4615028 - 873 WP_000921423.1 virulence factor BrkB family protein -
K7H10_RS22375 (4615022) 4615022..4615621 - 600 WP_000965695.1 glucose-1-phosphatase -
K7H10_RS22380 (4615812) 4615812..4616615 - 804 WP_000059693.1 DeoR/GlpR family DNA-binding transcription regulator -
K7H10_RS22385 (4616649) 4616649..4617545 - 897 WP_052934521.1 sugar kinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 104 a.a.        Molecular weight: 12432.40 Da        Isoelectric Point: 9.5334

>T214604 WP_000558166.1 NZ_CP082338:4611967-4612278 [Salmonella enterica subsp. enterica]
VHVISRKPFNEAMLMYPNHELALTELLNVLEKKTFTQPEEMKRYIPSLDNFKYRDKWWVIDVSGNSLRLISYIDFRLHKI
FVKHIVSHAEYDKLTAYYRGNKE

Download         Length: 312 bp

>T214604 NZ_CP110149:224744-225160 [Klebsiella pneumoniae]
GTGAACAAGACCTATATGCTCGACACCTGTATCTGCTCGTTCATCATGCGCGAGCAGCCGGAAGCCGTCCTGAAGCGCCT
GGAGCTGGCGGTGCTGCGCGGCCAGCGCATCGTTGTCTCGGCCATCACTTATTCTGAAATGCGCTTCGGGGCCACCGGCC
CGAAGGCCTCCCCGCGCCACGTCGAGCTGGTCGACGCGTTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCT
GCGGTGGACGCCACCACGGAGATTAAGGTGGCGCTGCGAATGGCCGGGACGCCGATCGGCCCGAACGACACGGCCATTGC
CGGGCACGCCATCGCCGCCGGTGCCGTGCTGGTGACGAATAATACGCGGGAATTTGAGCGGGTACCGGGTCTTGTGCTGG
AAGACTGGGTAAGATAA

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16734.08 Da        Isoelectric Point: 6.6451

>AT214604 WP_001259011.1 NZ_CP082338:4612275-4612721 [Salmonella enterica subsp. enterica]
MRTHRQMDATSAKKIVDTFSDAVKTVPLMGEDRNDNEYRRALALVEFLVDHDDLENPLFELLCARISEYEKHAPEFKALN
QHLEKTPPGVSVLRTLMDQYGLKAADLANELGSKSNVSNILNGRRALTVNHIKALTQRFKLPADAFIE

Download         Length: 447 bp

>AT214604 NZ_CP110149:224517-224747 [Klebsiella pneumoniae]
ATGAGAACTGTATCCATTTTTAAAAACGGCAATAACCGCGCCATTCGTCTGCCCCGCGATCTGGATTTTGAGGGAGTGAG
CGAGCTGGAGATCGTCCGGGAAGGGGACAGCATTATTTTGCGTCCCGTCCGGCCGACCTGGGGCTCGTTCGCGCAGTTCG
AGAAGGCAGACCCGGACTTTATGGCGGAGCGCGAGGACGTTGTCAGCGACGAAGGACGATTTAACCTGTGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0R9ME90


Antitoxin

Source ID Structure

References